ArticleAmerican journal of physiology. Endocrinology and metabolism2016
Insulin does not stimulate muscle protein synthesis during increased plasma branched-chain amino acids alone but still decreases whole body proteolysis in humans.
Article in American journal of physiology. Endocrinology and metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Association of Changes in Portal Insulin with Immunometabolism During and After Hepatitis C Virus Infection.Journal of clinical and translational hepatology · 2026Article
- Associations of Amino Acids with the Risk of Prediabetes: A Case-Control Study from Kazakhstan.Journal of personalized medicine · 2024Article
- Adverse Skeletal Muscle Adaptations in Individuals Born Preterm-A Comprehensive Review.Current issues in molecular biology · 2024Review
- Kinetic modeling of leucine-mediated signaling and protein metabolism in human skeletal muscle.iScience · 2024Article
- Role of branched-chain amino acid metabolism in the pathogenesis of obesity and type 2 diabetes-related metabolic disturbances BCAA metabolism in type 2 diabetes.Nutrition & diabetes · 2022Review
- Trans-omics analysis of insulin action reveals a cell growth subnetwork which co-regulates anabolic processes.iScience · 2022Article
- Interaction effect of systemic inflammation and modifiable rheumatoid cachexia risk factors on resting energy expenditure in patients with rheumatoid arthritis.JCSM clinical reports · 2022Article
- Skeletal muscle wasting after a severe burn is a consequence of cachexia and sarcopenia.JPEN. Journal of parenteral and enteral nutrition · 2021Review
- Gut Microbiota as the Link between Elevated BCAA Serum Levels and Insulin Resistance.Biomolecules · 2021Review
- Article
- Sarcopenia in women with hip fracture: A comparison of hormonal biomarkers and their relationship to skeletal muscle mass and function.Osteoporosis and sarcopenia · 2020Article
- Nutrient Timing: A Garage Door of Opportunity?Nutrients · 2020Review
- Regulation of Muscle Growth in Early Postnatal Life in a Swine Model.Annual review of animal biosciences · 2019Review
- Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks.iScience · 2018Article
- Proteolysis inhibition by hibernating bear serum leads to increased protein content in human muscle cells.Scientific reports · 2018Article
- Sarcopenia in the Cirrhotic Patient: Current Knowledge and Future Directions.Journal of clinical and experimental hepatologyReview
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Insulin stimulates muscle protein synthesis when the levels of total amino acids, or at least the essential amino acids, are at or above their postabsorptive concentrations. Among the essential amino acids, branched-chain amino acids (BCAA) have the primary role in stimulating muscle protein synthesis and are commonly sought alone to stimulate muscle protein synthesis in humans. Fourteen healthy young subjects were studied before and after insulin infusion to examine whether insulin stimulates muscle protein synthesis in relation to the availability of BCAA alone. One half of the subjects were studied in the presence of postabsorptive BCAA concentrations (control) and the other half in the presence of increased plasma BCAA (BCAA). Compared with that prior to the initiation of the insulin infusion, fractional synthesis rate of muscle protein (%/h) did not change (P > 0.05) during insulin in either the control (0.04 ± 0.01 vs 0.05 ± 0.01) or the BCAA (0.05 ± 0.02 vs. 0.05 ± 0.01) experiments. Insulin decreased (P < 0.01) whole body phenylalanine rate of appearance (μmol·kg
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.