ReviewProtein science : a publication of the Protein Society2016
Carboxylic ester hydrolases: Classification and database derived from their primary, secondary, and tertiary structures.
Review in Protein science : a publication of the Protein Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 59 citations in OpenAlex.
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- Crystal structure and biochemical analysis of acetylesterase (LgEstI) from Lactococcus garvieae.PloS one · 2023Article
- Metabolomic profiling and its association with the bio-efficacy ofFrontiers in microbiology · 2023Article
- Improved machine learning scoring functions for identification of Electrophorus electricus's acetylcholinesterase inhibitors.Molecular diversity · 2022Article
- Metagenomic Screening for Lipolytic Genes Reveals an Ecology-Clustered Distribution Pattern.Frontiers in microbiology · 2022Article
- Assessing and utilizing esterase specificity in antimicrobial prodrug development.Methods in enzymology · 2022Article
- RevisitingBiomolecules · 2021Article
- Endogenous Enzymes Enable Antimicrobial Activity.ACS chemical biology · 2021Article
- Halophilic archaea and their potential to generate renewable fuels and chemicals.Biotechnology and bioengineering · 2021Review
- DUB esterase activity further decodes ubiquitin's enigma.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Three photoinitiators induce breast tumor growth in mouse xenografts with MCF-7 breast cancer cells.Current research in toxicology · 2021Article
- A Conserved Carboxylesterase InhibitsViruses · 2020Article
- Transcriptome Profiling Provides Insights Into Potential Antagonistic Mechanisms Involved inFrontiers in microbiology · 2020Article
- Characterization and Immobilization of a Novel SGNH Family Esterase (International journal of molecular sciences · 2019Article
- High throughput metabolomics-proteomics investigation on metabolic phenotype changes in rats caused byRSC advances · 2019Article
- NOTUM inhibition increases endocortical bone formation and bone strength.Bone research · 2019Article
- A Feasibility Study on the Identification of Potential Biomarkers in Pulmonary Embolism Using Proteomic Analysis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We classified the carboxylic ester hydrolases (CEHs) into families and clans by use of multiple sequence alignments, secondary structure analysis, and tertiary structure superpositions. Our work for the first time has fully established their systematic structural classification. Family members have similar primary, secondary, and tertiary structures, and their active sites and reaction mechanisms are conserved. Families may be gathered into clans by their having similar secondary and tertiary structures, even though primary structures of members of different families are not similar. CEHs were gathered from public databases by use of Basic Local Alignment Search Tool (BLAST) and divided into 91 families, with 36 families being grouped into five clans. Members of one clan have standard α/β-hydrolase folds, while those of other two clans have similar folds but with different sequences of their β-strands. The other two clans have members with six-bladed β-propeller and three-α-helix bundle tertiary structures. Those families not in clans have a large variety of structures or have no members with known structures. At the time of writing, the 91 families contained 321,830 primary structures and 1378 tertiary structures. From these data, we constructed an accessible database: CASTLE (CArboxylic eSTer hydroLasEs, http://www.castle.cbe.iastate.edu).
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