ArticleNeurorehabilitation and neural repair2017
An Automated Test of Rat Forelimb Supination Quantifies Motor Function Loss and Recovery After Corticospinal Injury.
Article in Neurorehabilitation and neural repair, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Multimodal cortical and subcortical exercise compared with treadmill training for spinal cord injury.PloS one · 2018Trial
- AutoRG: An automatized reach-to-grasp platform technology for assessing forelimb motor function, neural circuit activation, and cognition in rodents.Journal of neuroscience methods · 2023Article
- Plasticity in Cervical Motor Circuits following Spinal Cord Injury and Rehabilitation.Biology · 2021Review
- Behavioral testing in animal models of spinal cord injury.Experimental neurology · 2020Review
- Automated Forelimb Tasks for Rodents: Current Advantages and Limitations, and Future Promise.Neurorehabilitation and neural repair · 2019Article
- Vagus Nerve Stimulation Enhances Stable Plasticity and Generalization of Stroke Recovery.Stroke · 2018Article
- Plasticity in One Hemisphere, Control From Two: Adaptation in Descending Motor Pathways After Unilateral Corticospinal Injury in Neonatal Rats.Frontiers in neural circuits · 2018Article
- The Knob Supination Task: A Semi-automated Method for Assessing Forelimb Function in Rats.Journal of visualized experiments : JoVE · 2017Article
- Dexterity: A MATLAB-based analysis software suite for processing and visualizing data from tasks that measure arm or forelimb function.Journal of neuroscience methods · 2017Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundRodents are the primary animal model of corticospinal injury and repair, yet current behavioral tests do not show the large deficits after injury observed in humans. Forearm supination is critical for hand function and is highly impaired by corticospinal injury in both humans and rats. Current tests of rodent forelimb function do not measure this movement.
objectiveTo determine if quantification of forelimb supination in rats reveals large-scale functional loss and partial recovery after corticospinal injury.
methodsWe developed a knob supination device that quantifies supination using automated and objective methods. Rats in a reaching box have to grasp and turn a knob in supination in order to receive a food reward. Performance on this task and the single pellet reaching task were measured before and after 2 manipulations of the pyramidal tract: a cut lesion of 1 pyramid and inactivation of motor cortex using 2 different drug doses.
resultsA cut lesion of the corticospinal tract produced a large deficit in supination. In contrast, there was no change in pellet retrieval success. Supination function recovered partially over 6 weeks after injury, and a large deficit remained. Motor cortex inactivation produced a dose-dependent loss of knob supination; the effect on pellet reaching was more subtle.
conclusionsThe knob supination task reveals in rodents 3 signature hand function changes observed in humans with corticospinal injury: (1) large-scale loss with injury, (2) partial recovery in the weeks after injury, and (3) loss proportional to degree of dysfunction.
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