Evidence map›Paper›PMID 27529811›Full record

ArticlePediatric research2016

Brief neonatal nutritional supplementation has sex-specific effects on glucose tolerance and insulin regulating genes in juvenile lambs.

Anne L Jaquiery, Sharon S Park, Hui Hui Phua, Mary J Berry, Daphne Meijler, Jane E Harding, Mark H Oliver, Frank H Bloomfield

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In one paragraph

Article in Pediatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Anne L JaquieryThe Liggins Institute, University of Auckland, Auckland, New Zealand.
Sharon S ParkThe Liggins Institute, University of Auckland, Auckland, New Zealand.
Hui Hui PhuaThe Liggins Institute, University of Auckland, Auckland, New Zealand.
Mary J BerryThe Liggins Institute, University of Auckland, Auckland, New Zealand.
Daphne MeijlerThe Liggins Institute, University of Auckland, Auckland, New Zealand.
Jane E HardingThe Liggins Institute, University of Auckland, Auckland, New Zealand.
Mark H OliverThe Liggins Institute, University of Auckland, Auckland, New Zealand.
Frank H BloomfieldThe Liggins Institute, University of Auckland, Auckland, New Zealand.
University of Auckland · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe nutritional plane and composition during fetal life can impact upon growth and epigenetic regulation of genes affecting pancreatic β-cell development and function. However, it is not clear whether β-cell development can be altered by nutritional factors or growth rate after birth. We therefore investigated the effect of neonatal nutritional supplements on growth, glucose tolerance, and pancreatic development in lambs.

methodsNewborn lambs were randomized to daily nutritional supplements, calculated to increase macronutrient intake to a similar degree as human breast milk fortifier, or an equivalent volume of water, for 2 wk while continuing to suckle ewe milk. Intravenous glucose tolerance test (IVGTT) was performed at 4 mo of age, and pancreata collected for molecular analysis.

resultsSupplemented lambs had slower weight gain than controls. In supplemented lambs, insulin response to IVGTT was increased in males but decreased in females, compared to same sex controls, and was unrelated to growth rate. mRNA expression of key genes in β-cell development showed sexually dimorphic effects. Epigenetic change occurred in the promotor region of PDX1 gene with decreased suppression and increased activation marks in supplemented lambs of both sexes.

conclusionNutritional interventions in early life have long-term, sex-specific effects on pancreatic function.

Indexed as

Animal Nutritional Physiological PhenomenaDietary SupplementsAnimal FeedAnimalsAnimals, NewbornEpigenesis, GeneticFemaleGlucose Tolerance TestGlucose Transporter Type 2Homeodomain ProteinsHumansInsulinInsulin-Like Growth Factor IIInsulin SecretionMaleMilkGlucose Transporter Type 2Homeodomain ProteinsInsulinInsulin-Like Growth Factor IIpancreatic and duodenal homeobox 1 proteinRNA, MessengerTrans-Activators

Identifiers

PMID27529811
OpenAlexW2508968943

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.