ArticleThe British journal of radiology2016
Shear wave elastography (SWE) of the spleen in patients with hepatitis B and C but without significant liver fibrosis.
Article in The British journal of radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic accuracy of spleen stiffness to evaluate portal hypertension and esophageal varices in chronic liver disease: a systematic review and meta-analysis.European radiology · 2021Pooled it
- Shear Wave Ultrasonographic Elastography in Pediatric Spleens and Its Role in Differential Diagnosis.Diagnostics (Basel, Switzerland) · 2024Article
- Spleen stiffness measurement as a non-invasive assessment in patients with portal hypertension.eGastroenterology · 2024Review
- Prognostic significance of spleen shear wave elastography and dispersion in patients with heart failure: the crucial role of cardio-splenic axis.Clinical research in cardiology : official journal of the German Cardiac Society · 2023Observational
- A Primer to the Diagnostic and Clinical Utility of Spleen Stiffness Measurement in Patients With Chronic Liver Disease.Clinical liver disease · 2022Review
- Alanine aminotransferase and spleno-portal dynamics affect spleen stiffness measured by point shear-wave elastography in patients with chronic hepatitis C in the absence of significant liver fibrosis.Journal of ultrasound · 2021Article
- Spleen elastography in patients with Systemic sclerosis.Rheumatology international · 2021Article
- The relationship of spleen stiffness value measured by shear wave elastography with age, gender, and spleen size in healthy volunteers.Journal of medical ultrasonics (2001) · 2019Article
- Measurement of splenic stiffness by 2D-shear wave elastography in patients with extrahepatic portal vein obstruction.The British journal of radiology · 2018Article
- Evaluation of Splenic Stiffness in Patients of Extrahepatic Portal Vein Obstruction Using 2D Shear Wave Elastography: Comparison with Intra-Operative Portal Pressure.Journal of clinical and experimental hepatology · 2018Article
- Clinical applications of spleen ultrasound elastography - a review.Journal of ultrasonography · 2018Review
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Authors and funding
10 authors.
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Abstract
objectiveThe aim of the study was to compare the elasticity of the spleen in patients with hepatitis B and C but without liver fibrosis with that of healthy subjects using a shear wave elastography (SWE) examination.
methodsBetween December 2014 and December 2015, 35 patients with hepatitis B virus (HBV) infections and 45 patients with (hepatitis C virus) HCV infections and liver stiffness below 7.1 kPa were included in the study. The control group was composed of 53 healthy volunteers without any chronic liver disease, with no abnormal findings in their ultrasound examinations and with an SWE of the liver below 6.5 kPa. The SWE measurements were a part of routine ultrasound abdominal examinations. The examinations were performed using an Aixplorer device by two radiologists with at least 6 years' experience. To compare spleen stiffness between the groups, the Mann-Whitney U-test was applied. To analyze the dependency between liver and spleen elasticity, Spearman's rank correlation coefficient was calculated.
resultsA total of 133 SWE findings were analyzed. Stiffness of the spleen was significantly higher in patients with HBV and HCV but without significant liver fibrosis than it was in the healthy controls (p = 0.0018 and 0.0000, respectively). This correlation was also present in patients with liver stiffness below 6.5 kPa (p = 0.0041 and 0.0000, respectively). Analysis revealed no significant correlation between liver and spleen stiffness in patients with hepatitis B and C and without significant fibrosis (p = 0.3216 and 0.0626, respectively).
conclusionPatients with hepatitis B and C but without significant liver fibrosis have stiffer spleens than healthy controls. There is no dependency between liver and spleen elasticity in patients without significant fibrosis. ADVANCES IN KNOWLEDGE: The SWE examination might be an important tool and could be used in addition to conventional imaging. Our study may become a starting point in further investigations into the role of the spleen in HCV and HBV infections and perhaps into introducing spleen elastography into diagnostic and follow-up procedures.
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