Evidence map›Paper›PMID 27529518›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2016

G Protein-Coupled Receptors Incorporated into Rehydrated Diblock Copolymer Vesicles Retain Functionality.

M Gertrude Gutierrez, Farzad Jalali-Yazdi, Justin Peruzzi, Carson T Riche, Richard W Roberts, Noah Malmstadt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

M Gertrude GutierrezMork Family Department of Chemical Engineering and Materials Science, University of Southern California, 925 Bloom Walk, Los Angeles, CA, 90089, USA.
Farzad Jalali-YazdiMork Family Department of Chemical Engineering and Materials Science, University of Southern California, 925 Bloom Walk, Los Angeles, CA, 90089, USA.
Justin PeruzziDepartment of Chemical Engineering, University of Virginia, 102 Engineers' Way, P.O. Box 400741, Charlottesville, VA, 22904-4741, USA.
Carson T RicheMork Family Department of Chemical Engineering and Materials Science, University of Southern California, 925 Bloom Walk, Los Angeles, CA, 90089, USA.
Richard W RobertsMork Family Department of Chemical Engineering & Materials Science, Department of Chemistry, Department of Molecular & Computational Biology, and USC Norris Comprehensive Cancer Center, University of Southern California, 925 Bloom Walk, Los Angeles, CA, 90089, USA.
Noah MalmstadtMork Family Department of Chemical Engineering & Materials Science, Department of Biomedical Engineering and Department of Chemistry, University of Southern California, 925 Bloom Walk, Los Angeles, CA, 90089, USA. malmstad@usc.edu.

Funding

Connecting plasma membrane function to lipid structure and organization with asymR01GM093279 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MALMSTADT, NOAH · 2010 to 2014
$1.4M
NIGMS NIH HHS R01 GM093279
6 · The paper itself

Abstract

G protein-coupled receptor (GPCR) is incorporated into polymeric vesicles made up of diblock copolymer bilayers. Successfully incorporated GPCRs exhibit correct biased physiological orientation and respond to various ligands. After extended dehydrated storage via lyophilization and subsequent rehydration, diblock copolymer polymersomes retain their shape and incorporated GPCR retains its function.

Indexed as

FluorescenceFreeze DryingLipid BilayersPolymersReceptor, Serotonin, 5-HT1AReceptors, G-Protein-CoupledSolutionsUnilamellar LiposomesLipid BilayersPolymersReceptor, Serotonin, 5-HT1AReceptors, G-Protein-CoupledSolutionsUnilamellar Liposomesbilayer vesiclesblock copolymersGPCRlyophilizationpolymersomes

Identifiers

PMID27529518
PMCPMC5148614

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.