Evidence map›Paper›PMID 27529288›Full record

ArticleJournal of neurochemistry2016

Mapping the alterations in glutamate with GluCEST MRI in a mouse model of dopamine deficiency.

Puneet Bagga, Rachelle Crescenzi, Guruprasad Krishnamoorthy, Gaurav Verma, Ravi Prakash Reddy Nanga, Damodar Reddy, Joel Greenberg, John A Detre, Hari Hariharan, Ravinder Reddy

Open access · bronzeAbstract read
In one paragraph

Article in Journal of neurochemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 50 citations in OpenAlex.

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  14. Accelerating GluCEST imaging using deep learning for BMagnetic resonance in medicine · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Puneet BaggaCenter for Magnetic Resonance and Optical Imaging (CMROI), Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Rachelle CrescenziCenter for Magnetic Resonance and Optical Imaging (CMROI), Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Guruprasad KrishnamoorthyCenter for Magnetic Resonance and Optical Imaging (CMROI), Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Gaurav VermaCenter for Magnetic Resonance and Optical Imaging (CMROI), Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Ravi Prakash Reddy NangaCenter for Magnetic Resonance and Optical Imaging (CMROI), Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Damodar ReddyCenter for Magnetic Resonance and Optical Imaging (CMROI), Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Joel GreenbergDepartment of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania.
John A DetreCenter for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania.
Hari HariharanCenter for Magnetic Resonance and Optical Imaging (CMROI), Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Ravinder ReddyCenter for Magnetic Resonance and Optical Imaging (CMROI), Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania. krr@upenn.edu.
Resonance Research (United States) · USUniversity of Pennsylvania · US

Funding

Training and DisseminationP41EB015893 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI REDDY, RAVINDER · 2012 to 2019
$11.3M
A Novel Method for Glutamate ImagingR01NS087516 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI REDDY, RAVINDER · 2014 to 2018
$1.7M
NIBIB NIH HHS P41 EB015893NINDS NIH HHS R01 NS087516
6 · The paper itself

Abstract

Glutamate chemical exchange saturation transfer (GluCEST) MRI was used to measure metabolic changes in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by mapping regional cerebral glutamate. The GluCEST contrast following MPTP treatment was correlated with

Indexed as

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsAstrocytesBrain ChemistryDopamineDopamine AgentsDyskinesia, Drug-InducedGlial Fibrillary Acidic ProteinGliosisGlutamic AcidHand StrengthMagnetic Resonance ImagingMaleMiceMice, Inbred C57BLMPTP Poisoning1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineDopamineDopamine AgentsGlial Fibrillary Acidic Proteinglial fibrillary astrocytic protein, mouseGlutamic AcidSlc17a7 protein, mouseTyrosine 3-MonooxygenaseVesicular Glutamate Transport Protein 1astrogliosisbrainCESTGFAPglutamateMRItyrosine hydroxylase

Identifiers

PMID27529288
PMCPMC5077646
OpenAlexW2516550544

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.