ArticleNutrients2016
Associations of Serum Manganese Levels with Prediabetes and Diabetes among ≥60-Year-Old Chinese Adults: A Population-Based Cross-Sectional Analysis.
Article in Nutrients, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 36 citations in OpenAlex.
- Associations of metal mixtures with insulin resistance and glucose homeostasis in U.S. adults from the NHANES 2011-2018.Scientific reports · 2026Article
- Association Between Serum Cobalt and Manganese Levels with Insulin Resistance in Overweight and Obese Mexican Women.Healthcare (Basel, Switzerland) · 2025Article
- Dietary mineral patterns are associated with the pre-diabetes regression and progression: the Tehran lipid and glucose study (TLGS).BMC nutrition · 2025Article
- Manganese exposure and its U-shaped relationship with diabetic retinopathy: analysis of NHANES 2011-2020.Frontiers in nutrition · 2025Article
- The relationship between serum manganese concentration with all-cause and cause-specific mortality: a retrospective and population-based cross-sectional study.BMC cardiovascular disorders · 2024Article
- Association between serum heavy metal levels and diabetic retinopathy in NHANES 2011-2020.Scientific reports · 2024Article
- Consequences of Disturbing Manganese Homeostasis.International journal of molecular sciences · 2023Review
- The Role of Natural Antioxidant Products That Optimize Redox Status in the Prevention and Management of Type 2 Diabetes.Antioxidants (Basel, Switzerland) · 2023Review
- Association between serum manganese and serum klotho in a 40-80-year-old American population from NHANES 2011-2016.Frontiers in aging · 2023Article
- Single and Combined Associations of Plasma and Urine Essential Trace Elements (Zn, Cu, Se, and Mn) with Cardiovascular Risk Factors in a Mediterranean Population.Antioxidants (Basel, Switzerland) · 2022Article
- Association between serum manganese levels and diabetes in Chinese adults with hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Alterations in manganese level in the biological samples of young obese Saudi women.Journal of Taibah University Medical Sciences · 2021Article
- Potential Health Risks of Macro- and Microelements in Commercial Medicinal Plants Used to Treatment of Diabetes.BioMed research international · 2021Article
- A P4 Medicine Perspective of Gut Microbiota and Prediabetes: Systems Analysis and Personalized Intervention.Journal of translational internal medicine · 2020Article
- Bile acid composition regulates the manganese transporter Slc30a10 in intestine.The Journal of biological chemistry · 2020Article
- Dietary manganese and type 2 diabetes mellitus: two prospective cohort studies in China.Diabetologia · 2018Article
- Trace element status in type 2 diabetes: A meta-analysis.Journal of clinical and diagnostic research : JCDR · 2018Article
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9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Older adults can experience glucose metabolism dysfunction, and although manganese may help regulate glucose metabolism, there is little information regarding this association among older people. This cross-sectional study included 2402 Chinese adults who were ≥60 years old in 2013 (Tianjin, China), and evaluated the associations of serum manganese with prediabetes and diabetes. Serum manganese levels were measured using inductively coupled plasma mass spectrometry. Multivariable logistic regression models were used to evaluate the sex-specific associations of manganese levels with diabetes and prediabetes after adjusting for confounding factors (age, sex, life style factors, and health status). Based on the WHO criteria, prediabetes was observed in 15.1% of men and 13.4% of women, while diabetes was observed in 30.0% of men and 34.4% of women. In the final model, the odds ratios (95% confidence interval) for prediabetes according to manganese quartile were 1.000, 0.463 (0.269-0.798), 0.639 (0.383-1.065), and 0.614 (0.365-1.031) among men and 1.000, 0.773 (0.498-1.200), 0.602 (0.382-0.947), and 0.603 (0.381-0.953) among women (p for trend = 0.134 and 0.015, respectively). The lowest prevalence of diabetes among men occurred at a moderate range of serum manganese (p < 0.05). Therefore, appropriate serum manganese levels may help prevent and control prediabetes and diabetes.
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