ReviewNutrients2016
Protein Requirements during Aging.
Review in Nutrients, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Incremental Hemodialysis: Review of Clinical Trials Focused on Patients Undergoing Once-Weekly Hemodialysis.Nutrients · 2025Pooled it
- Nutrition interventions for body composition, physical function, cognition in hospitalized older adults: A systematic review of individuals 75 years and older.Journal of the American Geriatrics Society · 2024Pooled it
- Estimating protein intake in sarcopenic older adults: combining food diaries and weighed powders versus 24-hour urine collections.The journal of nutrition, health & aging · 2025Trial
- Dietary protein intake is not associated with 5-y change in mid-thigh muscle cross-sectional area by computed tomography in older adults: the Health, Aging, and Body Composition (Health ABC) Study.The American journal of clinical nutrition · 2019Trial
- Simple and Robust Approach for Determination of Total Protein Content in Plant Samples.Foods (Basel, Switzerland) · 2025Article
- Can We Maintain Muscle Mass on a Plant-Based Diet?Current nutrition reports · 2025Review
- Nutritional Considerations During Major Weight Loss Therapy: Focus on Optimal Protein and a Low-Carbohydrate Dietary Pattern.Current nutrition reports · 2024Review
- Determining amino acid requirements in humans.Frontiers in nutrition · 2024Review
- Plant-based dietary pattern and low muscle mass: a nation-wide cohort analysis of Chinese older adults.BMC geriatrics · 2023Article
- Article
- Is It Time to Reconsider the U.S. Recommendations for Dietary Protein and Amino Acid Intake?Nutrients · 2023Review
- Impact of exercise and leucine-enriched protein supplementation on physical function, body composition, and inflammation in pre-frail older adults: a quasi-experimental study.Frontiers in medicine · 2023Article
- Impact of COVID-19 Infection and Persistent Lingering Symptoms on Patient Reported Indicators of Nutritional Risk and Malnutrition.Nutrients · 2022Article
- Dietary Intake Patterns of Community-Dwelling Older Adults After Acute Hospitalization.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Effect of Dietary Protein Intake on Bone Mineral Density and Fracture Incidence in Older Adults in the Health, Aging, and Body Composition Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Sarcopenia: Etiology, Nutritional Approaches, and miRNAs.International journal of molecular sciences · 2021Review
- Common Muscle Metabolic Signatures Highlight Arginine and Lysine Metabolism as Potential Therapeutic Targets to Combat Unhealthy Aging.International journal of molecular sciences · 2021Article
- Sustaining Protein Nutrition Through Plant-Based Foods.Frontiers in nutrition · 2021Review
- Relationship Between Sarcopenia and Cardiovascular Diseases in the Elderly: An Overview.Frontiers in cardiovascular medicine · 2021Review
- Green extraction of proteins, umami and other free amino acids from brown macroalgaeJournal of applied phycology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein recommendations for elderly, both men and women, are based on nitrogen balance studies. They are set at 0.66 and 0.8 g/kg/day as the estimated average requirement (EAR) and recommended dietary allowance (RDA), respectively, similar to young adults. This recommendation is based on single linear regression of available nitrogen balance data obtained at test protein intakes close to or below zero balance. Using the indicator amino acid oxidation (IAAO) method, we estimated the protein requirement in young adults and in both elderly men and women to be 0.9 and 1.2 g/kg/day as the EAR and RDA, respectively. This suggests that there is no difference in requirement on a gender basis or on a per kg body weight basis between younger and older adults. The requirement estimates however are ~40% higher than the current protein recommendations on a body weight basis. They are also 40% higher than our estimates in young men when calculated on the basis of fat free mass. Thus, current recommendations may need to be re-assessed. Potential rationale for this difference includes a decreased sensitivity to dietary amino acids and increased insulin resistance in the elderly compared with younger individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.