ArticleInternational journal of molecular sciences2016
Immunosuppressive Effect of Litsea cubeba L. Essential Oil on Dendritic Cell and Contact Hypersensitivity Responses.
Article in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Antimicrobial, Antioxidant, and Immunomodulatory Properties of Essential Oils: A Systematic Review.Nutrients · 2019Pooled it
- Exploring the anti-anaphylaxis potential of natural products: A Review.Inflammopharmacology · 2025Review
- Article
- Chemical Compositions and Antibacterial Activities ofJournal of agricultural and food chemistry · 2025Article
- A Comprehensive Review of Food-Derived Compounds Targeting Pyroptosis for Colitis Therapy: From Effects to Mechanisms.Journal of inflammation research · 2025Review
- Insect Bite Hypersensitivity in Horses: Causes, Diagnosis, Scoring and New Therapies.Animals : an open access journal from MDPI · 2023Review
- Solvent-Free Microwave Extraction of Essential Oils fromAntioxidants (Basel, Switzerland) · 2022Article
- The leaves of the seasoning plantFrontiers in nutrition · 2022Article
- An Overview on Total Valorization ofMolecules (Basel, Switzerland) · 2021Review
- Effects ofEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Evaluation of the Anti-Trypanosomal Activity of Vietnamese Essential Oils, with Emphasis onMolecules (Basel, Switzerland) · 2019Article
- Insights into Natural Products in Inflammation.International journal of molecular sciences · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Litsea cubeba L., also named as Makauy, is a traditional herb and has been used as cooking condiment or tea brewing to treat diseases for aborigines. The present study was undertaken to explore the chemical compositions of the fruit essential oil of L. cubeba (LCEO) and the immunomodulatory effect of LCEO on dendritic cells and mice. The LCEO was analyzed using gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS) with direct injection (DI/GC) or headspace-solid phase microextraction (HS-SPME/GC). In total, 56 components were identified, of which 48 were detected by DI/GC and 49 were detected by HS-SPME/GC. The principal compounds were citral (neral and geranial). An immunosuppressive activity of LCEO was investigated with bone marrow-derived dendritic cells (DCs) which have a critical role to trigger the adaptive immunity. Additionally, the inhibitory effect of LCEO on immune response was elucidated by performing the contact hypersensitivity (CHS) responses in mice. Our results clearly showed that LCEO decreases the production of TNF-α and cytokine IL-12 in a dose-dependent manner in lipopolysaccharide (LPS)-stimulated DCs. CHS response and the infiltrative T cells were inhibited in the tested ears of the mice co-treated with LCEO. We demonstrate, for the first time, that the LCEO mainly containing citral exhibits an immunosuppressive effect on DCs and mice, indicating that LCEO can potentially be applied in the treatment of CHS, inflammatory diseases, and autoimmune diseases.
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Registered trials
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