ReviewInternational journal of molecular sciences2016
The Potential Role of Kallistatin in the Development of Abdominal Aortic Aneurysm.
Review in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Kallistatin limits abdominal aortic aneurysm by attenuating generation of reactive oxygen species and apoptosis.Scientific reports · 2021Trial
- Altered expression and potential role of N6-methyladenosine mRNA methylation in abdominal aortic aneurysm mouse model.Scientific reports · 2025Article
- Risk Factors Affecting Morbidity and Mortality in Open Repair of Infrarenal Abdominal Aortic Aneurysms: A Retrospective Cohort Study in the University of the Philippines - Philippine General Hospital.Acta medica Philippina · 2025Article
- Angiogenesis in Aortic Aneurysm and Dissection: A Literature Review.Reviews in cardiovascular medicine · 2023Review
- Dysregulations of Key Regulators of Angiogenesis and Inflammation in Abdominal Aortic Aneurysm.International journal of molecular sciences · 2023Article
- The mechanism and therapy of aortic aneurysms.Signal transduction and targeted therapy · 2023Review
- Key ferroptosis-related genes in abdominal aortic aneurysm formation and rupture as determined by combining bioinformatics techniques.Frontiers in cardiovascular medicine · 2022Article
- TheInternational journal of women's health · 2021Article
- Meprin-α (Mep1A) enhances TNF-α secretion by mast cells and aggravates abdominal aortic aneurysms.British journal of pharmacology · 2020Article
- Kallistatin correlates with inflammation in abdominal aortic aneurysm and suppresses its formation in mice.Cardiovascular diagnosis and therapy · 2020Article
- Increased m6A methylation level is associated with the progression of human abdominal aortic aneurysm.Annals of translational medicine · 2019Article
- Is Abdominal Aortic Aneurysm Behavior after Endovascular Repair Associated with Aneurysm Wall Density on Computed Tomography Angiography?Medicina (Kaunas, Lithuania) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abdominal aortic aneurysm (AAA) is a vascular condition that causes permanent dilation of the abdominal aorta, which can lead to death due to aortic rupture. The only treatment for AAA is surgical repair, and there is no current drug treatment for AAA. Aortic inflammation, vascular smooth muscle cell apoptosis, angiogenesis, oxidative stress and vascular remodeling are implicated in AAA pathogenesis. Kallistatin is a serine proteinase inhibitor, which has been shown to have a variety of functions, potentially relevant in AAA pathogenesis. Kallistatin has been reported to have inhibitory effects on tumor necrosis factor alpha (TNF-α) signaling induced oxidative stress and apoptosis. Kallistatin also inhibits vascular endothelial growth factor (VEGF) and Wnt canonical signaling, which promote inflammation, angiogenesis, and vascular remodeling in various pre-clinical experimental models. This review explores the potential protective role of kallistatin in AAA pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.