Evidence map›Paper›PMID 27528996›Full record

ArticleMalawi medical journal : the journal of Medical Association of Malawi2005

Evaluation of antiretroviral therapy results in Blantyre, Malawi.

J J van Oosterhout, N Bodasing, J J Kumwenda, C Nyirenda, J Mallewa, P R Cleary, M P de Baar, R Schuurman, D M Burger, E E Zijlstra

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Malawi medical journal : the journal of Medical Association of Malawi, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

J J van OosterhoutDepartment of Medicine, College of Medicine, University of Malawi, Blantyre, Malawi.
N BodasingDepartment of Medicine, College of Medicine, University of Malawi, Blantyre, Malawi.
J J KumwendaDepartment of Medicine, College of Medicine, University of Malawi, Blantyre, Malawi.
C NyirendaDepartment of Medicine, College of Medicine, University of Malawi, Blantyre, Malawi; Queen Elizabeth Central Hospital, Department of Medicine, Blantyre, Malawi.
J MallewaDepartment of Medicine, College of Medicine, University of Malawi, Blantyre, Malawi; Queen Elizabeth Central Hospital, Department of Medicine, Blantyre, Malawi.
P R ClearyDepartment of Community Health, College of Medicine, University of Malawi, Blantyre, Malawi.
M P de BaarPrimagen, Amsterdam, the Netherlands.
R SchuurmanDepartment of Virology, University Medical Centre Utrecht, the Netherlands.
D M BurgerDepartment of Clinical Pharmacy, University Medical Centre Nijmegen, the Netherlands.
E E ZijlstraDepartment of Medicine, College of Medicine, University of Malawi, Blantyre, Malawi.
University of Malawi · MWRadboud University Medical Center · NLUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledWe performed a cross sectional study to evaluate treatment results of the paying antiretroviral therapy clinic of Queen Elizabeth Central Hospital, Blantyre. The only antiretroviral therapy was a fixed drug combination of stavudine, lamivudine and nevirapine.

methodsInterviews, laboratory tests (CD4 count, viral load, nevirapine plasma levels, transaminases) and data extraction from files. 422 (59 %) of the patients who started antiretroviral therapy since 2000 were lost to follow up. The 176 patients enrolled in the study had good virological and excellent clinical treatment results. The most common side effect was peripheral neuropathy. Nevirapine plasma levels were remarkably high and associated with successful virological treatment results. Two simple adherence questions pertaining to the use of medication in the previous 8 days corresponded well with nevirapine levels. The most important reasons for non-adherence were shortage of drugs in the hospital pharmacy and personal financial constraints.

conclusionsMany patients were lost to follow up.High nevirapine levels contributed to good therapy results in those studied.Simple adherence questions predicted sub-therapeutic nevirapine levels.Antiretroviral drug supply needs to be uninterrupted and free of charge, to prevent avoidable non-adherence.

Identifiers

PMID27528996
PMCPMC3345508
OpenAlexW2057943754

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.