ArticleInternational journal of endocrinology2016
Relationship between Branched-Chain Amino Acids, Metabolic Syndrome, and Cardiovascular Risk Profile in a Chinese Population: A Cross-Sectional Study.
Article in International journal of endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 62 citations in OpenAlex.
- Valine overproduction inMetabolic engineering communications · 2026Article
- Article
- Angel or demon? The dual role of branched-chain amino acids in chronic inflammatory and injury-related diseases.Frontiers in immunology · 2026Review
- Dietary branched-chain amino acids intake in relation to general and central obesity among Chinese children and adolescents: a cross-sectional study.Frontiers in nutrition · 2026Article
- Metabolomics and nutrient intake reveal metabolite-nutrient interactions in metabolic syndrome: insights from the Korean Genome and Epidemiology Study.Nutrition journal · 2025Article
- Article
- Serum tyrosine increases all-cause mortality in an older population.Frontiers in endocrinology · 2025Article
- Clinical metabolomics in type 2 diabetes mellitus: from pathogenesis to biomarkers.Frontiers in endocrinology · 2025Review
- Metabolic Signatures of Blood Pressure and Risk of Cardiovascular Diseases.Journal of the American Heart Association · 2024Article
- Branched-chain amino acids and the risk of hypertension; a persian cohort-based study.BMC cardiovascular disorders · 2024Article
- Duality of Branched-Chain Amino Acids in Chronic Cardiovascular Disease: Potential Biomarkers versus Active Pathophysiological Promoters.Nutrients · 2024Review
- Dietary amino acid profile and risk of hypertension: findings from the Ravansar cohort study.BMC nutrition · 2024Article
- Review
- Dietary intakes of branch chained amino acids and obesity risk among Chinese gestational diabetes women.Frontiers in nutrition · 2024Article
- Intake of dietary branched-chain amino acids reduces odds of metabolic syndrome: a cross-sectional study on the PERSIAN Kavar cohort study.Frontiers in nutrition · 2024Article
- Association between type 2 diabetes and branched chain amino acids (BCAA); a case-control study.Journal of diabetes and metabolic disorders · 2023Article
- A metabolomics-based analysis of the metabolic pathways associated with the regulation of branched-chain amino acids in rats fed a high-fructose diet.Endocrine connections · 2023Article
- Preliminary Study on the Association of Serum Branched-Chain Amino Acids With Lipid and Hepatic Markers.Cardiology research · 2023Article
- Metabolomic profiles in relapsing-remitting and progressive multiple sclerosis compared to healthy controls: a five-year follow-up study.Metabolomics : Official journal of the Metabolomic Society · 2023Article
- Association of Circulating Branched-Chain Amino Acids with Cardiovascular Diseases: A Mendelian Randomization Study.Nutrients · 2023Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective. This study aimed to evaluate the relationship between branched-chain amino acids (BCAAs), metabolic syndrome (MS), and other cardiovascular (CV) risk factors in middle-aged and elderly Chinese population at high risk for the development of cardiovascular disease (CVD). Methods. 1302 subjects were enrolled from the Huai'an Diabetes Prevention Program. Results. BCAAs levels were positively correlated with MS, its components, and CV risk profile. The odds ratio (OR) for MS among subjects in the fourth quartile of BCAAs levels showed a 2.17-fold increase compared with those in the first quartile. BCAAs were independently associated with high Framingham risk score even after adjusting for MS and its components (P < 0.0001). Additionally, the OR for high CV risk was 3.20-fold (P < 0.0001) in participants in the fourth BCAAs quartile with MS compared with participants in the first BCAAs quartile without MS. Conclusions. Increased BCAAs levels are independent risk factors of MS and CVD in addition to the traditional factors in middle-aged and elderly Chinese population. The development of CVD in MS patients with high level BCAAs is accelerated. Intervention studies are needed to investigate whether the strategy of BCAAs reduction has impacts on endpoints in patients with higher CV risk. This study is registered with ChiCTR-TRC-14005029.
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Registered trials
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