Evidence map›Paper›PMID 27528604›Full record

ArticleThe Journal of biological chemistry2016

The Vesicle Priming Factor CAPS Functions as a Homodimer via C2 Domain Interactions to Promote Regulated Vesicle Exocytosis.

Matt Petrie, Joseph Esquibel, Greg Kabachinski, Stephanie Maciuba, Hirohide Takahashi, J Michael Edwardson, Thomas F J Martin

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. PI(4,5)PBiochimica et biophysica acta. Molecular and cell biology of lipids · 2025
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Matt PetrieFrom the Department of Biochemistry, Integrated Program in Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, and.
Joseph EsquibelFrom the Department of Biochemistry, Program of Molecular and Cellular Pharmacology, and.
Greg KabachinskiFrom the Department of Biochemistry, Integrated Program in Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, and.ORCID http://orcid.org/0000-0003-4363-441X
Stephanie MaciubaFrom the Department of Biochemistry, Integrated Program in Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, and.
Hirohide Takahashithe Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, United Kingdom.
J Michael Edwardsonthe Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, United Kingdom.ORCID http://orcid.org/0000-0003-0499-7795
Thomas F J MartinFrom the Department of Biochemistry, Integrated Program in Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, and Program of Molecular and Cellular Pharmacology, and tfmartin@wisc.edu.ORCID http://orcid.org/0000-0002-5204-0202
University of Wisconsin–Madison · USUniversity of Cambridge · GB

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
Training Program In Molecular AND Cellular PharmacologyT32GM008688 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI AUDHYA, ANJON · 1998 to 2020
$6.0M
THE MECHANISM OF ACTION OF THYROTROPIN-RELEASING HORMONER01DK025861 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI MARTIN, THOMAS F. J. · 1986 to 2024
$5.6M
CA++ REGULATION OF SECRETION IN NEUROENDOCRINE CELLSR01DK040428 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI MARTIN, THOMAS F. J. · 1988 to 2015
$4.8M
Calcium Regulation of Secretion in Neuroendocrine CellsR01GM119158 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI MARTIN, THOMAS F. J. · 2016 to 2019
$1.3M
ACQUISITION OF MASS SPECTROMETER FOR CORE FACILITYS10RR013790 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI RAINES, RONALD T · 1999 to 1999
–
NCI NIH HHS P30 CA014520NCRR NIH HHS S10 RR013790NIDDK NIH HHS R01 DK025861NIDDK NIH HHS R01 DK040428NIGMS NIH HHS R01 GM119158NIGMS NIH HHS T32 GM008688
6 · The paper itself

Abstract

Neurotransmitters and peptide hormones are secreted by regulated vesicle exocytosis. CAPS (also known as CADPS) is a 145-kDa cytosolic and peripheral membrane protein required for vesicle docking and priming steps that precede Ca

Indexed as

AnimalsCalcium-Binding ProteinsExocytosisNerve Tissue ProteinsPC12 CellsPhosphatidylinositol 4,5-DiphosphateProtein DomainsProtein MultimerizationQ-SNARE ProteinsRatsSecretory VesiclesCadps protein, ratCalcium-Binding ProteinsNerve Tissue ProteinsPhosphatidylinositol 4,5-DiphosphateQ-SNARE ProteinsUnc13a protein, ratdimerizationexocytosisinositol phospholipidSNARE proteinsvesicles

Identifiers

PMID27528604
PMCPMC5076532
OpenAlexW2509153986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.