ArticleKidney international2016
The relatively poor correlation between random and 24-hour urine protein excretion in patients with biopsy-proven glomerular diseases.
Article in Kidney international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 75 citations in OpenAlex.
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- Clinical and Histologic Predictors of Kidney Outcomes in C3 Glomerulopathy and Idiopathic Membranoproliferative GN.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
- Proteinuria as an End Point in Clinical Trials of Focal Segmental Glomerulosclerosis.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2025Review
- IPNA consensus definitions for clinical trial outcomes in steroid-resistant nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2025Article
- Urine albumin-to-creatinine ratio diurnal variation rate predicts outcomes in idiopathic membranous nephropathy.Clinical and experimental nephrology · 2024Article
- The correlation of spot urinary protein-to-creatinine ratio with 24-h urinary protein excretion in various glomerulopathies.World journal of nephrology · 2023Article
- Mild mesangial proliferative IgA nephropathy with and without minimal change disease.Clinical and experimental medicine · 2023Article
- Randomized Trial on the Effect of an Oral Spleen Tyrosine Kinase Inhibitor in the Treatment of IgA Nephropathy.Kidney international reports · 2023Article
- Comparison of three spot proteinuria measurements for pediatric nephrotic syndrome: based on the International pediatric Nephrology Association 2022 Guidelines.Renal failure · 2023Article
- Dyslipidemia may be a risk factor for progression in children with IgA nephropathy.Pediatric nephrology (Berlin, Germany) · 2022Article
- External validation of the international prediction tool in Korean patients with immunoglobulin A nephropathy.Kidney research and clinical practice · 2022Article
- Diagnostic efficacy and influence factors of urinary protein/creatinine ratio replacing 24-h urine protein as an evaluator of proteinuria in children.International urology and nephrology · 2022Article
- RUMA and RUPCR in children with Henoch-Schonlein purpura.Journal of clinical laboratory analysis · 2022Article
- Correlation Between 24-Hour Urine Protein and Random Urine Protein-Creatinine Ratio in Amyloid Light-Chain Amyloidosis.Kidney medicine · 2022Article
- An equation to estimate 24-hour total urine protein excretion rate in patients who underwent urine protein testing.BMC nephrology · 2022Article
- Comparison of 24-h Urine Protein, Urine Albumin-to-Creatinine Ratio, and Protein-to-Creatinine Ratio in IgA Nephropathy.Frontiers in medicine · 2022Article
- The diagnostic value of native kidney biopsy in low grade, subnephrotic, and nephrotic range proteinuria: A retrospective cohort study.PloS one · 2022Article
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10 authors at 6 institutions in 2 countries.
Funding
Abstract
Random urine protein creatinine ratios are used to estimate 24-hour urine protein excretion, which is considered a diagnostic gold standard. However, few studies are available of the sensitivity and specificity of this estimation in patients with glomerular proteinuria. To clarify this, we measured the urine protein and creatinine centrally in random and 24-hour urine collections at biopsy and longitudinally every 6 months in individuals participating in the Nephrotic Syndrome Study Network (NEPTUNE) cohort with glomerular disease. In the initial developmental cohort, 302 patients had same day random and 24-hour samples with a total of 827 paired measurements across all visits. The protein excretion (g/day) was higher in adult than pediatric patients. The correlation between the random urine protein creatinine ratio and 24-hour urine protein excretion was moderate in both groups (r of 0.60 and 0.67, respectively). However, the log
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