ArticleKidney international2016
Renal dendritic cells sample blood-borne antigen and guide T-cell migration to the kidney by means of intravascular processes.
Article in Kidney international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Comparison of sepsis-associated acute kidney injury with different degrees and causes reveals patterns in mitochondrial metabolism and immune infiltration changes.Scientific reports · 2025Article
- Microvascular immunity is organ-specific and remodeled after kidney injury in mice.Nature communications · 2025Article
- Elucidating the complex interplay between chronic kidney disease and hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- T-Cell Mediated Immune Rejection of Beta-2-Microglobulin Knockout Induced Pluripotent Stem Cell-Derived Kidney Organoids.Stem cells translational medicine · 2024Article
- Mechanisms of inflammation modulation by different immune cells in hypertensive nephropathy.Frontiers in immunology · 2024Review
- Tissue-resident memory T cell maintenance during antigen persistence requires both cognate antigen and interleukin-15.Science immunology · 2023Article
- Insights into dendritic cell maturation during infection with application of advanced imaging techniques.Frontiers in cellular and infection microbiology · 2023Review
- Review
- Immune cell behaviour and dynamics in the kidney - insights from in vivo imaging.Nature reviews. Nephrology · 2022Review
- Three-Dimensional Visualization With Tissue Clearing Uncovers Dynamic Alterations of Renal Resident Mononuclear Phagocytes After Acute Kidney Injury.Frontiers in immunology · 2022Article
- Transcriptomic Analysis Identifies A Tolerogenic Dendritic Cell Signature.Frontiers in immunology · 2021Article
- Peritoneal GATA6+ macrophages function as a portal for Staphylococcus aureus dissemination.The Journal of clinical investigation · 2019Article
- Immunology of the ageing kidney.Nature reviews. Nephrology · 2019Review
- Renal immune surveillance and dipeptidase-1 contribute to contrast-induced acute kidney injury.The Journal of clinical investigation · 2018Article
- Four-Dimensional Imaging of T Cells in Kidney Transplant Rejection.Journal of the American Society of Nephrology : JASN · 2018Article
- Renal effects of cytokines in hypertension.Current opinion in nephrology and hypertension · 2018Review
- Effector CD4Nature communications · 2018Article
- Live-Animal Imaging of Renal Function by Multiphoton Microscopy.Current protocols in cytometry · 2018Article
- Opposing Roles of Dendritic Cell Subsets in Experimental GN.Journal of the American Society of Nephrology : JASN · 2018Article
- Role of the Immune System in Hypertension.Physiological reviews · 2017Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bony fish are among the first vertebrates to possess an innate and adaptive immune system. In these species, the kidney has a dual function: filtering solutes similar to mammals and acting as a lymphoid organ responsible for hematopoiesis and antigen processing. Recent studies have shown that the mammalian kidney has an extensive network of mononuclear phagocytes, whose function is not fully understood. Here, we employed two-photon intravital microscopy of fluorescent reporter mice to demonstrate that renal dendritic cells encase the microvasculature in the cortex, extend dendrites into the peritubular capillaries, and sample the blood for antigen. We utilized a mouse model of systemic bacterial infection as well as immune complexes to demonstrate antigen uptake by renal dendritic cells. As a consequence, renal dendritic cells mediated T-cell migration into the kidney in an antigen-dependent manner in the setting of bacterial infection. Thus, renal dendritic cells may be uniquely positioned to play an important role not only in surveillance of systemic infection but also in local infection and autoimmunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.