ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
Association of genotypes with viral load and biochemical markers in HCV-infected Sindhi patients.
Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Molecular evolution, virology and spatial distribution of HCV genotypes in Pakistan: A meta-analysis.Infectious medicine · 2023Article
- Distribution of HCV genotypes and HCV RNA viral load in hepatitis infected patients of Kolar region, Karnataka, India.Bioinformation · 2022Article
- Hepatitis C virus in Iran; transmission routes, growth in 3a genotype distribution, and lack of liver marker relation with genotypes.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2020Article
- An update on hepatitis C virus genotype distribution in Jordan: a 12-year retrospective study from a tertiary care teaching hospital in Amman.BMC infectious diseases · 2019Article
- Association of HCV genotype with viral load among Iranian blood donors: a penalized logistic regression.Medical journal of the Islamic Republic of Iran · 2019Article
- Hepatitis C subtype distribution in chronically infected patients with mild liver fibrosis in France: the GEMHEP study.Epidemiology and infection · 2019Article
- Hospital-visiting pregnant women signal an increased spread of hepatitis C infection in Khyber Pakhtunkhwa region of Pakistan.Virology journal · 2017Article
- Hepatitis C Virus in mainland China with an emphasis on genotype and subtype distribution.Virology journal · 2017Review
- Hepatitis C virus genotypes and associated risk factors in the state of Pará, Northern Brazil.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
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4 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The presented study had two objectives. The first was to examine distributions of Hepatitis C Virus (HCV) genotypes in Sindh, Pakistan, where HCV is prevalent. The other was to explore clinically relevant relationships between the genotypes, viral load (measured by real-time polymerase chain reaction assays) and biochemical markers. For this, 1471 HCV-infected patients in six cities in Sindh were recruited and sampled. HCV genotype distributions varied among the cities, but genotype 3a was most prevalent, followed by 3b, 1a and 1b (detected in 51.5, 22.7. 9.25 and 3.2% of the cases, respectively). No type-specific sequences were detected in serum samples from 189 (12.8%) of the 1471 patients. Frequencies of low (<200,000IU/mL serum), intermediate (200,000-600,000IU/mL serum) and high (>600,000IU/mL serum) viral loads were respectively 45.4, 16.5 and 38.1% for patients infected with genotype 3, and 16.9, 36.9 and 46.2%, respectively, for patients with other genotypes. Infection with genotype 1a was associated with significantly higher (p<0.005) alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase titers than infection with genotype 3a. The results will help in the formulation of treatment strategies.
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