ArticleG3 (Bethesda, Md.)2016
A Drosophila LexA Enhancer-Trap Resource for Developmental Biology and Neuroendocrine Research.
Article in G3 (Bethesda, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- The intestinal stem cell/enteroblast-GAL4 driver, escargot-GAL4, also manipulates gene expression in the juvenile hormone-synthesizing organ of Drosophila melanogaster.Scientific reports · 2024Article
- Expanding theeLife · 2024Article
- CRISPR/Cas9 gene editing inbioRxiv : the preprint server for biology · 2024Article
- Simplified homology-assisted CRISPR for gene editing in Drosophila.G3 (Bethesda, Md.) · 2024Article
- Generation of LexA enhancer-trap lines in Drosophila by an international scholastic network.G3 (Bethesda, Md.) · 2023Article
- Spatial and temporal control of expression with light-gated LOV-LexA.G3 (Bethesda, Md.) · 2022Article
- Independently paced Ca2+ oscillations in progenitor and differentiated cells in an ex vivo epithelial organ.Journal of cell science · 2022Article
- Transgenic Drosophila lines for LexA-dependent gene and growth regulation.G3 (Bethesda, Md.) · 2022Article
- Optogenetic approaches for understanding homeostatic and degenerative processes in Drosophila.Cellular and molecular life sciences : CMLS · 2021Review
- Tumors overcome the action of the wasting factor ImpL2 by locally elevating Wnt/Wingless.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Subpopulation of Macrophage-Like Plasmatocytes Attenuates Systemic Growth via JAK/STAT in theFrontiers in immunology · 2020Article
- Physiological and Pathological Regulation of Peripheral Metabolism by Gut-Peptide Hormones inFrontiers in physiology · 2020Review
- An Interscholastic Network To Generate LexA Enhancer Trap Lines inG3 (Bethesda, Md.) · 2019Article
- Fizzy-Related dictates A cell cycle switch during organ repair and tissue growth responses in theeLife · 2018Article
Corrections and comments
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Authors and funding
32 authors at 3 institutions in 1 country.
Funding
Abstract
Novel binary gene expression tools like the LexA-LexAop system could powerfully enhance studies of metabolism, development, and neurobiology in Drosophila However, specific LexA drivers for neuroendocrine cells and many other developmentally relevant systems remain limited. In a unique high school biology course, we generated a LexA-based enhancer trap collection by transposon mobilization. The initial collection provides a source of novel LexA-based elements that permit targeted gene expression in the corpora cardiaca, cells central for metabolic homeostasis, and other neuroendocrine cell types. The collection further contains specific LexA drivers for stem cells and other enteric cells in the gut, and other developmentally relevant tissue types. We provide detailed analysis of nearly 100 new LexA lines, including molecular mapping of insertions, description of enhancer-driven reporter expression in larval tissues, and adult neuroendocrine cells, comparison with established enhancer trap collections and tissue specific RNAseq. Generation of this open-resource LexA collection facilitates neuroendocrine and developmental biology investigations, and shows how empowering secondary school science can achieve research and educational goals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.