Evidence map›Paper›PMID 27527733›Full record

ArticleCancer research2016

Meeting Report: The Role of the Mobilome in Cancer.

Daniel Ardeljan, Martin S Taylor, Kathleen H Burns, Jef D Boeke, Michael Graham Espey, Elisa C Woodhouse, Thomas Kevin Howcroft

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Methods, Tools and Current Perspectives in Proteogenomics.Molecular & cellular proteomics : MCP · 2017
    Review
  2. Somatizing the transposons action.Mobile genetic elements · 2017
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daniel ArdeljanMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland. Medical Scientist Training Program, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Martin S TaylorDepartment of Pathology, Massachusetts General Hospital, Boston, Massachusetts.
Kathleen H BurnsMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Jef D BoekeInstitute for Systems Genetics, New York University Langone Medical Center, New York, New York.
Michael Graham EspeyDivision of Cancer Biology, NCI, NIH, Rockville, Maryland.
Elisa C WoodhouseDivision of Cancer Biology, NCI, NIH, Rockville, Maryland. woodhousee@mail.nih.gov.
Thomas Kevin HowcroftDivision of Cancer Biology, NCI, NIH, Rockville, Maryland.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007309 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI COX, ANDREA L · 1985 to 2019
$43.2M
TRAINING IN AREAS FUNDAMENTAL TO CANCER RESEARCHT32CA009110 · NCI · JOHNS HOPKINS UNIVERSITY · PI MATUNIS, MICHAEL J., WEERARATNA, ASHANI T · 1985 to 2025
$13.1M
Predoctoral Training Program in Human GeneticsT32GM007814 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 1985 to 2021
$10.6M
Training CoreP50GM107632 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BOEKE, JEF D · 2013 to 2017
$10.0M
Transposon Insertion Polymorphisms in Predispositions to Hematopoietic NeoplasiaR01CA163705 · NCI · JOHNS HOPKINS UNIVERSITY · PI BURNS, KATHLEEN H · 2013 to 2017
$1.7M
Intramural NIH HHS Z99 CA999999NCI NIH HHS R01 CA163705NCI NIH HHS T32 CA009110NIGMS NIH HHS P50 GM107632NIGMS NIH HHS T32 GM007309NIGMS NIH HHS T32 GM007814
6 · The paper itself

Abstract

Approximately half of the human genome consists of repetitive sequence attributed to the activities of mobile DNAs, including DNA transposons, RNA transposons, and endogenous retroviruses. Of these, only long interspersed elements (LINE-1 or L1) and sequences copied by LINE-1 remain mobile in our species today. Although cells restrict L1 activity by both transcriptional and posttranscriptional mechanisms, L1 derepression occurs in developmental and pathologic contexts, including many types of cancers. However, we have limited knowledge of the extent and consequences of L1 expression in premalignancies and cancer. Participants in this NIH strategic workshop considered key questions to enhance our understanding of mechanisms and roles the mobilome may play in cancer biology. Cancer Res; 76(15); 4316-9. ©2016 AACR.

Indexed as

HumansNeoplasmsRetroelementsRetroelements

Identifiers

PMID27527733
PMCPMC4991632

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.