ArticleAllergy2017
GPR91 deficiency exacerbates allergic contact dermatitis while reducing arthritic disease in mice.
Article in Allergy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
- Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota.The ISME journal · 2018Trial
- Retiring M1/M2: a view from the succinate receptor.Apoptosis : an international journal on programmed cell death · 2026Article
- Acarbose redirects gut microbiome utilization of dietary carbohydrates to suppress anaphylaxis in mice.Nature microbiology · 2026Article
- Emerging roles of the metabolite succinate in bone-related diseases.Journal of Zhejiang University. Science. B · 2025Review
- Succinate in innate immunity: linking metabolic reprogramming to immune modulation.Frontiers in immunology · 2025Review
- G protein-coupled receptor 91 activations suppressed mineralization in Porphyromonas gingivalis-infected osteoblasts.Scientific reports · 2024Article
- Single-cell RNA-sequencing of human eosinophils in allergic inflammation in the esophagus.The Journal of allergy and clinical immunology · 2024Article
- Cellular succinate metabolism and signaling in inflammation: implications for therapeutic intervention.Frontiers in immunology · 2024Review
- Article
- Orphan receptor GPR50 attenuates inflammation and insulin signaling in 3T3-L1 preadipocytes.FEBS open bio · 2023Article
- Review
- Targeting the succinate receptor effectively inhibits periodontitis.Cell reports · 2022Article
- Activation of succinate receptor 1 boosts human mast cell reactivity and allergic bronchoconstriction.Allergy · 2022Article
- SUCNR1 Mediates the Priming Step of the Inflammasome in Intestinal Epithelial Cells: Relevance in Ulcerative Colitis.Biomedicines · 2022Article
- Mechanism of succinate efflux upon reperfusion of the ischaemic heart.Cardiovascular research · 2021Article
- Multifaceted Actions of Succinate as a Signaling Transmitter Vary with Its Cellular Locations.Endocrinology and metabolism (Seoul, Korea) · 2020Review
- Association Between Succinate Receptor SUCNR1 Expression and Immune Infiltrates in Ovarian Cancer.Frontiers in molecular biosciences · 2020Article
- Inhibition of GPR91 Reduces Inflammatory Mediators Involved in Active Labor in Myometrium.Mediators of inflammation · 2020Article
- Gut microbiota-derived succinate: Friend or foe in human metabolic diseases?Reviews in endocrine & metabolic disorders · 2019Review
- SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity.Nature immunology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSuccinate, in addition to its role as an intermediary of the citric acid cycle, acts as an alarmin, initiating and propagating danger signals resulting from tissue injury or inflammatory stimuli. The contribution of this immune sensing pathway to the development of allergic and inflammatory responses is unknown.
methodsEar thickness of wild-type (wt) and Sucnr1-deficient (Sucnr1
resultsWe found augmented ACD reactions in Sucnr1
conclusionsA deficiency in succinate sensing during mast cell development confers these cells with a hyperactive phenotype. Such a phenomenon does not translate into exacerbation of asthma or mast cell-dependent arthritis. On the contrary, the fact that Sucnr1
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.