GuidelineNeurology2016
Neurocognitive outcomes in neurofibromatosis clinical trials: Recommendations for the domain of attention.
2 registry-linked trialsOpen access · bronzeAbstract readConsensus StatementPractice Guideline
In one paragraph
Guideline in Neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 13 papers.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Antioxidant Therapy With N-acetylcysteine for Learning and Motor Behavior in Children With Neurofibromatosis Type 1
Antioxidant Therapy With N-acetylcysteine for Motor Behavior and/or Learning in Children With Neurofibromatosis Type 1
Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Reproducibility of cognitive endpoints in clinical trials: lessons from neurofibromatosis type 1.Annals of clinical and translational neurology · 2019Trial
- The Lack of Ad Hoc Neuropsychological Assessment in Adults with Neurofibromatosis: A Systematic Review.Journal of clinical medicine · 2024Review
- Neurofibromatosis Type 1: Optimizing Management with a Multidisciplinary Approach.Journal of multidisciplinary healthcare · 2024Review
- Longitudinal association between executive function and academic achievement in children with neurofibromatosis type 1 and plexiform neurofibromas.Journal of the International Neuropsychological Society : JINS · 2023Article
- Verbal learning and memory in youth with neurofibromatosis type 1 and plexiform neurofibromas: Relationships with disease severity.European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society · 2022Article
- Innovation in the treatment of persistent pain in adults with Neurofibromatosis Type 1 (NF1): Implementation of the iCanCope mobile application.Contemporary clinical trials communications · 2022Article
- Attention and Motor Learning in Adult Patients with Neurofibromatosis Type 1.Journal of attention disorders · 2022Article
- Psychometric Properties of Attention Measures in Young Children with Neurofibromatosis Type 1: Preliminary Findings.Journal of pediatric neuropsychology · 2022Article
- Neurofibromatosis Clinical Trials-REiNS Collaboration 2020 Recommendations: Looking Back and Moving Ahead.Neurology · 2021Article
- An executive functioning perspective in neurofibromatosis type 1: from ADHD and autism spectrum disorder to research domains.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Review
- The TAND checklist: a useful screening tool in children with tuberous sclerosis and neurofibromatosis type 1.Orphanet journal of rare diseases · 2020Article
- Implications of new understandings of gliomas in children and adults with NF1: report of a consensus conference.Neuro-oncology · 2020Article
- An update on the central nervous system manifestations of neurofibromatosis type 1.Acta neuropathologica · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 1 country.
Karin S WalshFrom the Children's National Health System (K.S.W., K.K.H.), The George Washington School of Medicine, Washington, DC; Children's Hospital Colorado (J.J.), University of Colorado School of Medicine, Aurora; Pediatric Oncology Branch (P.L.W., S.M.), National Cancer Institute, Bethesda, MD; University of Wisconsin-Milwaukee (B.P.K.-T.); Clinical Research Directorate/Clinical Monitoring Research Program (M.A.T.-T.), Leidos Biomedical Research, Inc., NCI at Frederick, MD; California State University (H.L.T.), Sacramento; Murdoch Children's Research Institute (J.M.P.), Victoria, Australia; Rainbow Babies & Children's Hospital (P.d.B.), Cleveland, OH; Roosevelt University (C.S.), Chicago, IL; Boston Children's Hospital (L.S.G., N.U.), MA; and University of Vermont (S.E.S.), Burlington. kwalsh@childrensnational.org.
Jennifer JanuszFrom the Children's National Health System (K.S.W., K.K.H.), The George Washington School of Medicine, Washington, DC; Children's Hospital Colorado (J.J.), University of Colorado School of Medicine, Aurora; Pediatric Oncology Branch (P.L.W., S.M.), National Cancer Institute, Bethesda, MD; University of Wisconsin-Milwaukee (B.P.K.-T.); Clinical Research Directorate/Clinical Monitoring Research Program (M.A.T.-T.), Leidos Biomedical Research, Inc., NCI at Frederick, MD; California State University (H.L.T.), Sacramento; Murdoch Children's Research Institute (J.M.P.), Victoria, Australia; Rainbow Babies & Children's Hospital (P.d.B.), Cleveland, OH; Roosevelt University (C.S.), Chicago, IL; Boston Children's Hospital (L.S.G., N.U.), MA; and University of Vermont (S.E.S.), Burlington.
Pamela L WoltersFrom the Children's National Health System (K.S.W., K.K.H.), The George Washington School of Medicine, Washington, DC; Children's Hospital Colorado (J.J.), University of Colorado School of Medicine, Aurora; Pediatric Oncology Branch (P.L.W., S.M.), National Cancer Institute, Bethesda, MD; University of Wisconsin-Milwaukee (B.P.K.-T.); Clinical Research Directorate/Clinical Monitoring Research Program (M.A.T.-T.), Leidos Biomedical Research, Inc., NCI at Frederick, MD; California State University (H.L.T.), Sacramento; Murdoch Children's Research Institute (J.M.P.), Victoria, Australia; Rainbow Babies & Children's Hospital (P.d.B.), Cleveland, OH; Roosevelt University (C.S.), Chicago, IL; Boston Children's Hospital (L.S.G., N.U.), MA; and University of Vermont (S.E.S.), Burlington.
Staci MartinFrom the Children's National Health System (K.S.W., K.K.H.), The George Washington School of Medicine, Washington, DC; Children's Hospital Colorado (J.J.), University of Colorado School of Medicine, Aurora; Pediatric Oncology Branch (P.L.W., S.M.), National Cancer Institute, Bethesda, MD; University of Wisconsin-Milwaukee (B.P.K.-T.); Clinical Research Directorate/Clinical Monitoring Research Program (M.A.T.-T.), Leidos Biomedical Research, Inc., NCI at Frederick, MD; California State University (H.L.T.), Sacramento; Murdoch Children's Research Institute (J.M.P.), Victoria, Australia; Rainbow Babies & Children's Hospital (P.d.B.), Cleveland, OH; Roosevelt University (C.S.), Chicago, IL; Boston Children's Hospital (L.S.G., N.U.), MA; and University of Vermont (S.E.S.), Burlington.
Bonita P Klein-TasmanFrom the Children's National Health System (K.S.W., K.K.H.), The George Washington School of Medicine, Washington, DC; Children's Hospital Colorado (J.J.), University of Colorado School of Medicine, Aurora; Pediatric Oncology Branch (P.L.W., S.M.), National Cancer Institute, Bethesda, MD; University of Wisconsin-Milwaukee (B.P.K.-T.); Clinical Research Directorate/Clinical Monitoring Research Program (M.A.T.-T.), Leidos Biomedical Research, Inc., NCI at Frederick, MD; California State University (H.L.T.), Sacramento; Murdoch Children's Research Institute (J.M.P.), Victoria, Australia; Rainbow Babies & Children's Hospital (P.d.B.), Cleveland, OH; Roosevelt University (C.S.), Chicago, IL; Boston Children's Hospital (L.S.G., N.U.), MA; and University of Vermont (S.E.S.), Burlington.
Mary Anne Toledo-TamulaFrom the Children's National Health System (K.S.W., K.K.H.), The George Washington School of Medicine, Washington, DC; Children's Hospital Colorado (J.J.), University of Colorado School of Medicine, Aurora; Pediatric Oncology Branch (P.L.W., S.M.), National Cancer Institute, Bethesda, MD; University of Wisconsin-Milwaukee (B.P.K.-T.); Clinical Research Directorate/Clinical Monitoring Research Program (M.A.T.-T.), Leidos Biomedical Research, Inc., NCI at Frederick, MD; California State University (H.L.T.), Sacramento; Murdoch Children's Research Institute (J.M.P.), Victoria, Australia; Rainbow Babies & Children's Hospital (P.d.B.), Cleveland, OH; Roosevelt University (C.S.), Chicago, IL; Boston Children's Hospital (L.S.G., N.U.), MA; and University of Vermont (S.E.S.), Burlington.
Heather L ThompsonFrom the Children's National Health System (K.S.W., K.K.H.), The George Washington School of Medicine, Washington, DC; Children's Hospital Colorado (J.J.), University of Colorado School of Medicine, Aurora; Pediatric Oncology Branch (P.L.W., S.M.), National Cancer Institute, Bethesda, MD; University of Wisconsin-Milwaukee (B.P.K.-T.); Clinical Research Directorate/Clinical Monitoring Research Program (M.A.T.-T.), Leidos Biomedical Research, Inc., NCI at Frederick, MD; California State University (H.L.T.), Sacramento; Murdoch Children's Research Institute (J.M.P.), Victoria, Australia; Rainbow Babies & Children's Hospital (P.d.B.), Cleveland, OH; Roosevelt University (C.S.), Chicago, IL; Boston Children's Hospital (L.S.G., N.U.), MA; and University of Vermont (S.E.S.), Burlington.
Jonathan M PayneFrom the Children's National Health System (K.S.W., K.K.H.), The George Washington School of Medicine, Washington, DC; Children's Hospital Colorado (J.J.), University of Colorado School of Medicine, Aurora; Pediatric Oncology Branch (P.L.W., S.M.), National Cancer Institute, Bethesda, MD; University of Wisconsin-Milwaukee (B.P.K.-T.); Clinical Research Directorate/Clinical Monitoring Research Program (M.A.T.-T.), Leidos Biomedical Research, Inc., NCI at Frederick, MD; California State University (H.L.T.), Sacramento; Murdoch Children's Research Institute (J.M.P.), Victoria, Australia; Rainbow Babies & Children's Hospital (P.d.B.), Cleveland, OH; Roosevelt University (C.S.), Chicago, IL; Boston Children's Hospital (L.S.G., N.U.), MA; and University of Vermont (S.E.S.), Burlington.
Kristina K HardyFrom the Children's National Health System (K.S.W., K.K.H.), The George Washington School of Medicine, Washington, DC; Children's Hospital Colorado (J.J.), University of Colorado School of Medicine, Aurora; Pediatric Oncology Branch (P.L.W., S.M.), National Cancer Institute, Bethesda, MD; University of Wisconsin-Milwaukee (B.P.K.-T.); Clinical Research Directorate/Clinical Monitoring Research Program (M.A.T.-T.), Leidos Biomedical Research, Inc., NCI at Frederick, MD; California State University (H.L.T.), Sacramento; Murdoch Children's Research Institute (J.M.P.), Victoria, Australia; Rainbow Babies & Children's Hospital (P.d.B.), Cleveland, OH; Roosevelt University (C.S.), Chicago, IL; Boston Children's Hospital (L.S.G., N.U.), MA; and University of Vermont (S.E.S.), Burlington.
Peter de BlankFrom the Children's National Health System (K.S.W., K.K.H.), The George Washington School of Medicine, Washington, DC; Children's Hospital Colorado (J.J.), University of Colorado School of Medicine, Aurora; Pediatric Oncology Branch (P.L.W., S.M.), National Cancer Institute, Bethesda, MD; University of Wisconsin-Milwaukee (B.P.K.-T.); Clinical Research Directorate/Clinical Monitoring Research Program (M.A.T.-T.), Leidos Biomedical Research, Inc., NCI at Frederick, MD; California State University (H.L.T.), Sacramento; Murdoch Children's Research Institute (J.M.P.), Victoria, Australia; Rainbow Babies & Children's Hospital (P.d.B.), Cleveland, OH; Roosevelt University (C.S.), Chicago, IL; Boston Children's Hospital (L.S.G., N.U.), MA; and University of Vermont (S.E.S.), Burlington.
Claire SemerjianFrom the Children's National Health System (K.S.W., K.K.H.), The George Washington School of Medicine, Washington, DC; Children's Hospital Colorado (J.J.), University of Colorado School of Medicine, Aurora; Pediatric Oncology Branch (P.L.W., S.M.), National Cancer Institute, Bethesda, MD; University of Wisconsin-Milwaukee (B.P.K.-T.); Clinical Research Directorate/Clinical Monitoring Research Program (M.A.T.-T.), Leidos Biomedical Research, Inc., NCI at Frederick, MD; California State University (H.L.T.), Sacramento; Murdoch Children's Research Institute (J.M.P.), Victoria, Australia; Rainbow Babies & Children's Hospital (P.d.B.), Cleveland, OH; Roosevelt University (C.S.), Chicago, IL; Boston Children's Hospital (L.S.G., N.U.), MA; and University of Vermont (S.E.S.), Burlington.
Laura Schaffner GrayFrom the Children's National Health System (K.S.W., K.K.H.), The George Washington School of Medicine, Washington, DC; Children's Hospital Colorado (J.J.), University of Colorado School of Medicine, Aurora; Pediatric Oncology Branch (P.L.W., S.M.), National Cancer Institute, Bethesda, MD; University of Wisconsin-Milwaukee (B.P.K.-T.); Clinical Research Directorate/Clinical Monitoring Research Program (M.A.T.-T.), Leidos Biomedical Research, Inc., NCI at Frederick, MD; California State University (H.L.T.), Sacramento; Murdoch Children's Research Institute (J.M.P.), Victoria, Australia; Rainbow Babies & Children's Hospital (P.d.B.), Cleveland, OH; Roosevelt University (C.S.), Chicago, IL; Boston Children's Hospital (L.S.G., N.U.), MA; and University of Vermont (S.E.S.), Burlington.
Sondra E SolomonFrom the Children's National Health System (K.S.W., K.K.H.), The George Washington School of Medicine, Washington, DC; Children's Hospital Colorado (J.J.), University of Colorado School of Medicine, Aurora; Pediatric Oncology Branch (P.L.W., S.M.), National Cancer Institute, Bethesda, MD; University of Wisconsin-Milwaukee (B.P.K.-T.); Clinical Research Directorate/Clinical Monitoring Research Program (M.A.T.-T.), Leidos Biomedical Research, Inc., NCI at Frederick, MD; California State University (H.L.T.), Sacramento; Murdoch Children's Research Institute (J.M.P.), Victoria, Australia; Rainbow Babies & Children's Hospital (P.d.B.), Cleveland, OH; Roosevelt University (C.S.), Chicago, IL; Boston Children's Hospital (L.S.G., N.U.), MA; and University of Vermont (S.E.S.), Burlington.
Nicole UllrichFrom the Children's National Health System (K.S.W., K.K.H.), The George Washington School of Medicine, Washington, DC; Children's Hospital Colorado (J.J.), University of Colorado School of Medicine, Aurora; Pediatric Oncology Branch (P.L.W., S.M.), National Cancer Institute, Bethesda, MD; University of Wisconsin-Milwaukee (B.P.K.-T.); Clinical Research Directorate/Clinical Monitoring Research Program (M.A.T.-T.), Leidos Biomedical Research, Inc., NCI at Frederick, MD; California State University (H.L.T.), Sacramento; Murdoch Children's Research Institute (J.M.P.), Victoria, Australia; Rainbow Babies & Children's Hospital (P.d.B.), Cleveland, OH; Roosevelt University (C.S.), Chicago, IL; Boston Children's Hospital (L.S.G., N.U.), MA; and University of Vermont (S.E.S.), Burlington.
REiNS International Collaboration
National Cancer Institute · USUniversity of Colorado Denver · USUniversity of Colorado Hospital · USWashington School of Psychiatry · US
Funding
Mouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SAHIN, MUSTAFA · 2016 to 2020
$5.2MNICHD NIH HHS U54 HD090255
Abstract
Neurofibromatosis type 1 (NF1) is associated with neurocognitive deficits that can impact everyday functioning of children, adolescents, and adults with this disease. However, there is little agreement regarding measures to use as cognitive endpoints in clinical trials. This article describes the work of the Neurocognitive Committee of the Response Evaluation in Neurofibromatosis and Schwannomatosis (REiNS) International Collaboration. The goal of this committee is to identify standardized and specific cognitive assessment tools for use in NF clinical trials. The committee first identified cognitive domains relevant to NF1 and prioritized attention as the first domain of focus given prior and current trends in NF1 cognitive clinical trials. Performance measures and behavioral rating questionnaires of attention were reviewed by the group using established criteria to assess patient characteristics, psychometric properties, and feasibility. The highest rated tests underwent side-by-side comparison. The Digit Span subtest from the Wechsler scales was given the highest ratings of the performance measures due to its good psychometrics, feasibility, utility across a wide age range, and extensive use in previous research. The Conners scales achieved the highest ratings of the behavioral questionnaires for similar reasons. Future articles will focus on other cognitive domains, with the ultimate goal of achieving agreement for cognitive endpoints that can be used across NF clinical trials.
Indexed as
AttentionNeuropsychological TestsClinical Trials as TopicHumansNeurofibromatosis 1Treatment Outcome
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT04481035ClinicalTrials.gov
NCT04481048ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.