ArticleThe American journal of tropical medicine and hygiene2016
Aeromonas-Associated Diarrhea in Children Under 5 Years: The GEMS Experience.
Article in The American journal of tropical medicine and hygiene, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Trial
- Infectious Diarrhea in Early Childhood across the Global South: Etiologic Diversity and Pathogenic Mechanisms.ACS infectious diseases · 2026Review
- Aeromonas in South Asia: genomic insights into an environmental pathogen and reservoir of antimicrobial resistance.Nature communications · 2026Article
- Pathogen-specific predicting factors of childhood diarrhoea and their seasonality: evaluation from Rohingya refugees and host population in Cox's Bazar, Bangladesh.Journal of global health · 2026Article
- Characterization of the role of putativeJournal of bacteriology · 2026Article
- Human macrophage response to the emerging enteric pathogenVirulence · 2025Article
- Draft genomes ofMicrobiology resource announcements · 2025Article
- Clinico-Epidemiological Characteristics of Symptomatic and Asymptomatic Enterotoxigenic and Enteropathogenic Escherichia Coli Diarrhea and Impact on Child Growth.The American journal of tropical medicine and hygiene · 2025Article
- Evaluation of the prevalence of Aeromonas spp., Campylobacter spp., and Clostridioides difficile in immunocompromised children with diarrhea.BMC infectious diseases · 2024Article
- Analysis of globalMicrobial genomics · 2024Article
- Genomic analysis of clinicalMicrobial genomics · 2024Article
- EmergingFrontiers in microbiology · 2024Article
- Correlation between gut microbiota composition, enteric infections and linear growth impairment: a case-control study in childhood stunting in Pidie, Aceh, Indonesia.Gut pathogens · 2023Article
- EntericMicrobiology spectrum · 2023Article
- Prevalence ofChildren (Basel, Switzerland) · 2022Article
- Benefits and Risks of Smallholder Livestock Production on Child Nutrition in Low- and Middle-Income Countries.Frontiers in nutrition · 2021Review
- Associations between Household-Level Exposures and All-Cause Diarrhea and Pathogen-Specific Enteric Infections in Children Enrolled in Five Sentinel Surveillance Studies.International journal of environmental research and public health · 2020Article
- An Update on the GenusMicroorganisms · 2020Review
- Waterborne Infections in Reunion Island, 2010-2017.The American journal of tropical medicine and hygiene · 2018Observational
- Gut Microbiome Analysis Identifies Potential Etiological Factors in Acute Gastroenteritis.Infection and immunity · 2018Article
Corrections and comments
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Authors and funding
30 authors at 10 institutions in 9 countries.
Funding
Abstract
We report the clinical findings, epidemiology, and risk factors for moderate-to-severe diarrhea (MSD) associated with Aeromonas species in children 0-59 months of age, from the Global Enteric Multicenter Study, conducted at three sites in south Asia and four sites in sub-Saharan Africa. Children with MSD were enrolled along with controls matched for age, gender, and neighborhood. Pooled, age-stratified conditional logistic regression models were applied to evaluate the association of Aeromonas infection controlling for coinfecting pathogens and sociodemographic variables. A pooled, age-stratified, multivariate logistic regression analysis was done to identify risk factors associated with Aeromonas positivity in MSD cases. A total of 12,110 cases and 17,291 matched controls were enrolled over a period of 48 months. Aeromonas was identified as a significant pathogen in 736 cases of MSD in Pakistan and Bangladesh (22.2%). Aeromonas remained a significant pathogen even after adjustment for the presence of other pathogens and sociodemographic factors. Odds ratio (OR) for Aeromonas were higher in the presence of Shigella (matched OR: 6.2, 95% confidence interval [CI]: 1.9-20.2). Cases of Aeromonas were likely to present with dysentery, particularly in the 0-11 months (OR: 1.4, 95% CI 1.0-2.0) and 12-23 months (OR: 1.8, 95% CI: 1.3-2.5) age group. The odds of Aeromonas increased with increasing degree of stunting, being highest for severe stunting (OR: 10.1, 95% CI: 3.6-28.9). Aeromonas is a significant pathogen for MSD in Pakistan and Bangladesh. Presence of dysentery and co-occurrence with other pathogens, notably Shigella spp. are significant features of Aeromonas-associated diarrhea.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.