ReviewCold Spring Harbor perspectives in biology2016
The Need for Integrated Approaches in Metabolic Engineering.
Review in Cold Spring Harbor perspectives in biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Balancing Cell Growth and Product Synthesis for Efficient Microbial Cell Factories.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Metabolic engineering for the production of acetoin and 2,3-butanediol at elevated temperature inFrontiers in bioengineering and biotechnology · 2023Article
- Marine Macrolides to Tackle Antimicrobial Resistance ofMarine drugs · 2022Review
- Rebooting life: engineering non-natural nucleic acids, proteins and metabolites in microorganisms.Microbial cell factories · 2022Review
- A Promiscuous Bacterial P450: The Unparalleled Diversity of BM3 in Pharmaceutical Metabolism.International journal of molecular sciences · 2021Review
- Future trends in synthetic biology in Asia.Advanced genetics (Hoboken, N.J.) · 2021Article
- Application of combinatorial optimization strategies in synthetic biology.Nature communications · 2020Review
- Nature's Chemists: The Discovery and Engineering of Phytochemical Biosynthesis.Frontiers in chemistry · 2020Review
- Engineering actinomycetes for biosynthesis of macrolactone polyketides.Microbial cell factories · 2019Review
- Adaptive Strategies of the Candidate Probiotic E. coli Nissle in the Mammalian Gut.Cell host & microbe · 2019Article
- Challenges and tackles in metabolic engineering for microbial production of carotenoids.Microbial cell factories · 2019Review
- An estimate is worth about a thousand experiments: using order-of-magnitude estimates to identify cellular engineering targets.Microbial cell factories · 2018Review
- Spatially organizing biochemistry: choosing a strategy to translate synthetic biology to the factory.Scientific reports · 2018Article
- A combinatorial approach to synthetic transcription factor-promoter combinations for yeast strain engineering.Yeast (Chichester, England) · 2018Article
- Microbial Platform for Terpenoid Production:Frontiers in microbiology · 2018Article
- Engineering Saccharomyces cerevisiae for geranylgeraniol overproduction by combinatorial design.Scientific reports · 2017Article
- Gas fermentation: cellular engineering possibilities and scale up.Microbial cell factories · 2017Review
- Alternative Watson-Crick Synthetic Genetic Systems.Cold Spring Harbor perspectives in biology · 2016Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review highlights state-of-the-art procedures for heterologous small-molecule biosynthesis, the associated bottlenecks, and new strategies that have the potential to accelerate future accomplishments in metabolic engineering. We emphasize that a combination of different approaches over multiple time and size scales must be considered for successful pathway engineering in a heterologous host. We have classified these optimization procedures based on the "system" that is being manipulated: transcriptome, translatome, proteome, or reactome. By bridging multiple disciplines, including molecular biology, biochemistry, biophysics, and computational sciences, we can create an integral framework for the discovery and implementation of novel biosynthetic production routes.
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Registered trials
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