ReviewJournal of veterinary internal medicine2016
Pathophysiology, Clinical Importance, and Management of Neurogenic Lower Urinary Tract Dysfunction Caused by Suprasacral Spinal Cord Injury.
Review in Journal of veterinary internal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 65 citations in OpenAlex.
- Low-frequency bladder vibration for the treatment of urinary tract infections in spinal cord injury patients with neurogenic bladder.International urology and nephrology · 2025Trial
- Trial
- Effectiveness of transcutaneous tibial nerve stimulation on anticholinergic refractory neurogenic detrusor overactivity in individuals with suprasacral spinal cord injury: A urodynamic study.The journal of spinal cord medicine · 2026Article
- Redefining bladder sympathetic Innervation with three-dimensional image reconstruction.Scientific reports · 2026Article
- Rational Use of Bethanechol in Dogs and Cats with Bladder Dysfunction.Veterinary sciences · 2025Review
- Article
- Window entrapment trauma in cats: clinical, neurological and clinicopathological findings and outcome (70 cases).Journal of feline medicine and surgery · 2024Article
- An innovative electrical neurostimulation approach to mimic reflexive urination control in spinal cord injury models.Scientific reports · 2024Article
- Assessment of the quality of life of cats affected by paraparesis/paraplegia and urinary retention, and their impact on caregivers.Journal of feline medicine and surgery · 2024Article
- Clinical Occurrences in the Neurorehabilitation of Dogs with Severe Spinal Cord Injury.Animals : an open access journal from MDPI · 2023Article
- Article
- Electromyography of the External Anal Sphincter during Micturition and Electrophysiological Bulbocavernosus Reflex in Healthy Spayed Female Canines.Veterinary medicine international · 2023Article
- Article
- Long-Term Surveillance and Management of Urological Complications in Chronic Spinal Cord-Injured Patients.Journal of clinical medicine · 2022Review
- A review of the neural control of micturition in dogs and cats: neuroanatomy, neurophysiology and neuroplasticity.Veterinary research communications · 2022Review
- Clinical and demographic predictors of symptoms of depression and anxiety in patients with spinal cord injury.Spinal cord · 2022Article
- Prevalence of bacteriuria in cats with neurogenic bladder.Veterinary research communications · 2022Article
- Association between age and incidence of deep vein thrombosis in patients with spinal cord injury: an observational cross-sectional study.Spinal cord · 2022Observational
- A survey of clinical practice concerning long-term follow-up of neurogenic lower urinary tract dysfunction due to spinal cord injury in Italy.The journal of spinal cord medicine · 2022Article
- Sacral neuromodulation for neurological disease-induced lower urinary tract symptoms in Saudi Arabia: a single-centre experience.The Journal of international medical research · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Management of persistent lower urinary tract dysfunction resulting from severe thoracolumbar spinal cord injury can be challenging. Severe suprasacral spinal cord injury releases the spinal cord segmental micturition reflex from supraspinal modulation and increases nerve growth factor concentration in the bladder wall, lumbosacral spinal cord, and dorsal root ganglion, which subsequently activates hypermechanosensitive C-fiber bladder wall afferents. Hyperexcitability of bladder afferents and detrusor overactivity can cause urine leaking during the storage phase. During urine voiding, the loss of supraspinal control that normally coordinates detrusor contraction with sphincter relaxation can lead to spinal cord segmental reflex-mediated simultaneous detrusor and sphincter contractions or detrusor-sphincter dyssynergia, resulting in inefficient urine voiding and high residual volume. These disease-associated changes can impact on the quality of life and life expectancy of spinal-injured animals. Here, we discuss the pathophysiology and management considerations of lower urinary tract dysfunction as the result of severe, acute, suprasacral spinal cord injury. In addition, drawing from experimental, preclinical, and clinical medicine, we introduce some treatment options for neurogenic lower urinary tract dysfunction that are designed to: (1) prevent urine leakage arising because of detrusor overactivity during bladder filling, (2) preserve upper urinary tract integrity and function by reducing intravesical pressure and subsequent vesicoureteral reflux, and (3) prevent urinary tract and systemic complications by treating and preventing urinary tract infections.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.