ArticleInternational journal of molecular sciences2016
Bioinformatics and Microarray Analysis of miRNAs in Aged Female Mice Model Implied New Molecular Mechanisms for Impaired Fracture Healing.
Article in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Prognostic and therapeutic potential of microRNAs for fracture healing processes and non-union fractures: A systematic review.Clinical and translational medicine · 2023Pooled it
- Systemic inflammatory and gut microbiota responses to fracture in young and middle-aged mice.GeroScience · 2023Article
- Novel scaffold platforms for simultaneous induction osteogenesis and angiogenesis in bone tissue engineering: a cutting-edge approach.Journal of nanobiotechnology · 2023Review
- Multiple targets identified with genome wide profiling of small RNA and mRNA expression are linked to fracture healing in mice.Bone reports · 2021Article
- Masquelet's induced membrane technique: Review of current concepts and future directions.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Review
- Protective effect and mechanism of microRNA-146a on ankle fracture.Experimental and therapeutic medicine · 2020Article
- Experimental study of expression profile and specific role of human microRNAs in regulating atrophic bone nonunion.Medicine · 2020Observational
- The Life of a Fracture: Biologic Progression, Healing Gone Awry, and Evaluation of Union.JBJS reviews · 2020Review
- Epidemiology, Clinical Assessments, and Current Treatments of Nonunions.Current osteoporosis reports · 2020Review
- Exosomal miRNA-128-3p from mesenchymal stem cells of aged rats regulates osteogenesis and bone fracture healing by targeting Smad5.Journal of nanobiotechnology · 2020Article
- LCK rs10914542-G allele associates with type 1 diabetes in children via T cell hyporesponsiveness.Pediatric research · 2019Article
- Deregulation of SATB2 in carcinogenesis with emphasis on miRNA-mediated control.Carcinogenesis · 2019Review
- The Therapeutic Potential of MicroRNAs as Orthobiologics for Skeletal Fractures.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Review
- Interleukin-7 gene polymorphism rs766736182 associates with the risk of asthma in children.Journal of clinical laboratory analysis · 2019Article
- Association of HLA-DQA1 gene polymorphisms with the risk of children primary nephrotic syndrome in Chinese population.Journal of clinical laboratory analysis · 2019Article
- Molecular pathogenesis of fracture nonunion.Journal of orthopaedic translation · 2018Review
- Transcriptional Mechanisms of Secondary Fracture Healing.Current osteoporosis reports · 2018Review
- Therapeutic monoclonal antibodies and clinical laboratory tests: When, why, and what is expected?Journal of clinical laboratory analysis · 2018Review
- MicroRNAs in orthopaedic research: Disease associations, potential therapeutic applications, and perspectives.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Review
- Precision medicine for hepatocellular carcinoma: driver mutations and targeted therapy.Oncotarget · 2017Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Impaired fracture healing in aged females is still a challenge in clinics. MicroRNAs (miRNAs) play important roles in fracture healing. This study aims to identify the miRNAs that potentially contribute to the impaired fracture healing in aged females. Transverse femoral shaft fractures were created in adult and aged female mice. At post-fracture 0-, 2- and 4-week, the fracture sites were scanned by micro computed tomography to confirm that the fracture healing was impaired in aged female mice and the fracture calluses were collected for miRNA microarray analysis. A total of 53 significantly differentially expressed miRNAs and 5438 miRNA-target gene interactions involved in bone fracture healing were identified. A novel scoring system was designed to analyze the miRNA contribution to impaired fracture healing (RCIFH). Using this method, 11 novel miRNAs were identified to impair fracture healing at 2- or 4-week post-fracture. Thereafter, function analysis of target genes was performed for miRNAs with high RCIFH values. The results showed that high RCIFH miRNAs in aged female mice might impair fracture healing not only by down-regulating angiogenesis-, chondrogenesis-, and osteogenesis-related pathways, but also by up-regulating osteoclastogenesis-related pathway, which implied the essential roles of these high RCIFH miRNAs in impaired fracture healing in aged females, and might promote the discovery of novel therapeutic strategies.
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Registered trials
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