Evidence map›Paper›PMID 27527077›Full record

ArticleBMC infectious diseases2016

Characteristics of serogroup 20 S.pneumoniae isolates from Brazil.

Juliana Caierão, Fernando Hayashi Sant'Anna, Paulina Hawkins, Gabriela Rosa Cunha, Mariana Mott, Diego Rodrigues Falci, Pedro Alves d'Azevedo, Lesley McGee, Cícero Dias

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Genomic analysis ofMicrobial genomics · 2023
    Article
  3. Theoretical pneumococcal vaccine coverage: analysis of serotypes isolated from inpatients at a tertiary care hospital.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Juliana CaierãoBasic Health Department, Federal University of Health Science of Porto Alegre, Porto Alegre, Brazil. julianaca@ufcspa.edu.br.
Fernando Hayashi Sant'AnnaGenetic Departament, Bioscience Institute, Center of Agricultural Microbiology Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Paulina HawkinsRollins School of Public Health, Emory University, Atlanta, USA.
Gabriela Rosa CunhaBasic Health Department, Federal University of Health Science of Porto Alegre, Porto Alegre, Brazil.
Mariana MottBasic Health Department, Federal University of Health Science of Porto Alegre, Porto Alegre, Brazil.
Diego Rodrigues FalciConceição Hospital Group, Porto Alegre, Brazil.
Pedro Alves d'AzevedoBasic Health Department, Federal University of Health Science of Porto Alegre, Porto Alegre, Brazil.
Lesley McGeeRespiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, USA.
Cícero DiasBasic Health Department, Federal University of Health Science of Porto Alegre, Porto Alegre, Brazil.
Universidade Federal de Ciências da Saúde de Porto Alegre · BRCenters for Disease Control and Prevention · USEmory University · USGrupo Hospitalar Conceição · BRUniversidade Federal do Rio Grande do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough serogroup 20 is not part of any conjugate pneumococcal vaccine, its serotype 20A, but not 20B, belongs to the polysaccharide 23-valent formula. Little is known about its clinical, laboratorial and epidemiological characteristics.

methodsThe purpose of this study was to evaluate the bacterial genotypes (by PFGE and MLST), clinical characteristics of patients (from review of medical records) and antimicrobial susceptibility of serogroup 20 isolates which were recovered from patients with invasive pneumococcal disease (IPD) from 2007 to 2012. Subtyping to determine 20A and 20B types was also performed by sequencing the genes of the cps locus.

resultsSixteen isolates were genotyped and were highly related. All pneumococci were resistant to tetracycline and 31 % were non-susceptible to trimethoprim/sulfamethoxazole. Penicillin MIC ranged from 0.004 to 1 μg/mL and non-susceptibility (MIC ≥ 0.12 μg/mL) was observed in 5/16 isolates (31 %). All isolates belonged to subtype 20B. Most patients were male with a median age of 62 years and presented at least one underlying disease (mostly respiratory conditions). All isolates belonged to ST8889 and to a unique PFGE clone.

conclusionsA high clonal occurrence of serotype 20B pneumococci recovered from patients with IPD in Brazil was observed. As a non-PCV10 serotype, selective pressure may be responsible for this unusual occurrence of serogroup 20. However, temporal variation effect should not be underestimated; therefore it is an issue that warrants continued monitoring.

Indexed as

AdultAgedAged, 80 and overAnti-Bacterial AgentsBacterial ProteinsBrazilCerebrospinal FluidDrug Resistance, BacterialElectrophoresis, Gel, Pulsed-FieldFemaleGenotypeHumansMaleMicrobial Sensitivity TestsMiddle AgedMultilocus Sequence TypingAnti-Bacterial AgentsBacterial ProteinsTetracyclineInvasive pneumococcal diseaseMolecular epidemiologySerogroup 20Streptococcus pneumoniae

Identifiers

PMID27527077
PMCPMC4986405
OpenAlexW2510787073

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.