ArticleJournal of the American Chemical Society2016
Characterization of Methanobactin from Methylosinus sp. LW4.
Article in Journal of the American Chemical Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Phylogenomic Identification of a Highly Conserved Copper-Binding RiPP Biosynthetic Gene Cluster in MarineACS chemical biology · 2025Article
- Inverse stable isotope probing-metabolomics (InverSIP) identifies an iron acquisition system in a methane-oxidizing bacterial community.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Methanobactins: Structures, Biosynthesis, and Microbial Diversity.Annual review of microbiology · 2024Review
- Chalkophomycin Biosynthesis Revealing Unique Enzyme Architecture for a Hybrid Nonribosomal Peptide Synthetase and Polyketide Synthase.Molecules (Basel, Switzerland) · 2024Article
- Unusual cysteine modifications in natural product biosynthesis.RSC chemical biology · 2024Review
- Direct Methane Oxidation by Copper- and Iron-Dependent Methane Monooxygenases.Chemical reviews · 2024Review
- Purification and biochemical characterization of methanobactin biosynthetic enzymes.Methods in enzymology · 2024Article
- A mixed-valent Fe(II)Fe(III) species converts cysteine to an oxazolone/thioamide pair in methanobactin biosynthesis.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Crystal structure and catalytic mechanism of the MbnBC holoenzyme required for methanobactin biosynthesis.Cell research · 2022Article
- MbnC Is Not Required for the Formation of the N-Terminal Oxazolone in the Methanobactin from Methylosinus trichosporium OB3b.Applied and environmental microbiology · 2022Article
- Characterization of a Copper-Chelating Natural Product from the MethanotrophBiochemistry · 2021Article
- Oxygen Generation via Water Splitting by a Novel Biogenic Metal Ion-Binding Compound.Applied and environmental microbiology · 2021Article
- MbnH is a diheme MauG-like protein associated with microbial copper homeostasis.The Journal of biological chemistry · 2019Article
- Repurposed HisC Aminotransferases Complete the Biosynthesis of Some Methanobactins.Biochemistry · 2018Article
- Chalkophores.Annual review of biochemistry · 2018Review
- Methanobactins: Maintaining copper homeostasis in methanotrophs and beyond.The Journal of biological chemistry · 2018Review
- Insight into Metal Removal from Peptides that Sequester Copper for Methane Oxidation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018Article
- The biosynthesis of methanobactin.Science (New York, N.Y.) · 2018Article
- Metals and Methanotrophy.Applied and environmental microbiology · 2018Review
- Methanobactins: from genome to function.Metallomics : integrated biometal science · 2017Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Methanobactins (Mbns) are a growing family of ribosomally produced, post-translationally modified natural products. Characteristic nitrogen-containing heterocycles and neighboring thioamides allow these compounds to bind copper with high affinity. Genome mining has enabled the identification of Mbn operons in bacterial genomes and the prediction of diverse Mbn structures from operon content and precursor peptide sequence. Here we report the characterization of Mbn from Methylosinus (Ms.) species (sp.) LW4. The peptide backbone is distinct from all previously characterized Mbns, and the post-translational modifications correspond precisely to those predicted on the basis of the Ms. sp. LW4 Mbn operon. Thus, prediction based on genome analysis combined with isolation and structural characterization represents a phylogenetic approach to finding diverse Mbns and elucidating their biosynthetic pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.