Evidence map›Paper›PMID 27527002›Full record

ArticleAIDS research and human retroviruses2017

Association of T Cell and Macrophage Activation with Arterial Vascular Health in HIV.

Heather N Grome, Louise Barnett, Cindy C Hagar, David G Harrison, Spyros A Kalams, John R Koethe

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in AIDS research and human retroviruses, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04439448 (An Observational Cohort Study of Adipose Tissue and Immune Activation in Treated HIV Infection), which is not on this map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04439448 completednot on this map

An Observational Cohort Study of Adipose Tissue and Immune Activation in Treated HIV Infection

TypeobservationalSponsorVanderbilt University Medical CenterRan2013 to 2020Enrolled100ConditionsHuman Immunodeficiency Virus, ObesityArmsdual-energy X-ray absorptiometry (DEXA) scan, Carotid and branchial artery ultrasound, 2-hour oral glucose tolerace test, Blood collection
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. CD3bioRxiv : the preprint server for biology · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Anticytomegalovirus CD4Arteriosclerosis, thrombosis, and vascular biology · 2021
    Article
  7. Article
  8. Article
  9. Article
  10. Leptin Promotes Greater Ki67 Expression in CD4Frontiers in immunology · 2021
    Article
  11. Article
  12. Article
  13. Coronary Microvascular Dysfunction in HIV: A Review.Journal of the American Heart Association · 2020
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Role of the Immune System in Hypertension.Physiological reviews · 2017
    Review
  19. HIV-1-Associated Atherosclerosis: Unraveling the Missing Link.Journal of the American College of Cardiology · 2017
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Heather N Grome1 Department of Medicine, Vanderbilt University Medical Center , Nashville, Tennessee.
Louise Barnett2 Division of Infectious Diseases, Vanderbilt University Medical Center , Nashville, Tennessee.
Cindy C Hagar2 Division of Infectious Diseases, Vanderbilt University Medical Center , Nashville, Tennessee.
David G Harrison3 Division of Clinical Pharmacology, Vanderbilt University Medical Center , Nashville, Tennessee.
Spyros A Kalams2 Division of Infectious Diseases, Vanderbilt University Medical Center , Nashville, Tennessee.
John R Koethe2 Division of Infectious Diseases, Vanderbilt University Medical Center , Nashville, Tennessee.
Vanderbilt University Medical Center · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
Tennessee CFAR: Implementation of Culturally Responsive Trauma-Informed Care with Youth with HIV in Memphis, TNP30AI110527 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI John Koethe · 2015 to 2026
$27.5M
REGULATION OF VASCULAR FUNCTION BY THE ENDOTHELIUMR01HL039006 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARRISON, DAVID G · 1987 to 2017
$5.5M
Mentoring in HIV and Tuberculosis ResearchK24AI065298 · NIAID · VANDERBILT UNIVERSITY · PI STERLING, TIMOTHY R · 2005 to 2014
$1.6M
The Role of The T Cell In The Genesis of Hypertension R01HL125865 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARRISON, DAVID G · 2015 to 2017
$1.2M
The Role of Obesity and Adipocytes in Immune Activation on Antiretroviral TherapyK23AI100700 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KOETHE, JOHN · 2012 to 2016
$600k
NCI NIH HHS P30 CA068485NCRR NIH HHS UL1 RR024975NHLBI NIH HHS R01 HL039006NHLBI NIH HHS R01 HL125865NIAID NIH HHS K23 AI100700NIAID NIH HHS K24 AI065298NIAID NIH HHS P30 AI110527
6 · The paper itself

Abstract

HIV-infected individuals are at increased risk of cardiovascular disease (CVD), but the arterial vascular functions affected by persistent innate and cellular immune activation are not well described. We assessed the relationship between immunologic and vascular parameters in 70 HIV-infected adults on efavirenz, tenofovir, and emtricitabine with more than 2 years of virologic suppression and no history of CVD. We measured brachial artery flow-mediated dilation (FMD) using ultrasound and circulating intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) by multiple immunoassay. We also measured circulating naive (CD45RO

Indexed as

Lymphocyte ActivationMacrophage ActivationAdultAlkynesAnti-HIV AgentsBenzoxazinesBrachial ArteryCardiovascular DiseasesCyclopropanesEmtricitabineFemaleFlow CytometryHIV InfectionsHumansImmunoassayIntercellular Adhesion Molecule-1AlkynesAnti-HIV AgentsBenzoxazinesCyclopropanesefavirenzEmtricitabineIntercellular Adhesion Molecule-1TenofovirVascular Cell Adhesion Molecule-1cardiovascularendotheliumflow-mediated dilationHIVimmune activation

Identifiers

PMID27527002
PMCPMC5312611
OpenAlexW2519595224

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.