ArticleNature genetics2016
Genetic variation in ZmVPP1 contributes to drought tolerance in maize seedlings.
Article in Nature genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 297 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
297 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-Quantitative Trait Loci Analysis and Candidate Gene Mining for Drought Tolerance-Associated Traits in Maize (International journal of molecular sciences · 2024Pooled it
- Multienvironment multilocus association mapping reveals genomic regions for drought-related traits in tropical maize.G3 (Bethesda, Md.) · 2026Article
- Review
- Genome-Wide and GWAS Dissection of Maize Fibrillin Genes Reveals Plastid Regulators of Drought and Salt Stress Tolerance.Current issues in molecular biology · 2026Article
- Conditionally Significant eQTL and TWAS Analyses Identify MsRD26 as a Major Candidate Positive Regulator of Salt Tolerance in Medicago sativa L.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Identification of a Major QTL Controlling Maize Lateral Root Branching Number Through Integrated BSA-Seq and Transcriptome Analysis.International journal of molecular sciences · 2026Article
- Root hair plasticity in cereals under abiotic stress.The New phytologist · 2026Review
- Genetic coupling of leaf and kernel-related traits shapes drought adaptation in maize.The Plant journal : for cell and molecular biology · 2026Article
- Article
- Natural variation inScience advances · 2026Article
- Genome-wide association study reveals the genetic architecture of drought tolerance in maize using yield-based resistance indices and transcriptomic evidence.The plant genome · 2026Article
- Unveiling genetic loci and natural alleles for seed iron accumulation in adzuki bean via genome-wide association study.BMC plant biology · 2026Article
- Multi-omics analysis reveals molecular mechanisms of maize responses to hexavalent chromium toxicity.BMC plant biology · 2026Article
- CQD: A Rapid and Accurate Tool for Identifying High-Confidence QTLs and Candidate Genes from GWAS Summary Statistics.International journal of molecular sciences · 2026Article
- Profiling the epigenomic landscape of late embryonic and adult mouse hind limb muscles.Scientific reports · 2026Article
- Exogenous melatonin on photosynthesis and physiological characteristics in maize under drought stress.BMC plant biology · 2026Article
- Genomic basis underlying alternative transcripts-mediated drought tolerance in maize.Genome biology · 2026Article
- Unlocking tropical adaptation: novel flowering time genes implicate JA and ROS signaling in maize.BMC plant biology · 2026Article
- Drought stress inFrontiers in plant science · 2026Review
- Battle of Arbuscular Mycorrhizal Fungi Against Drought Stress: A Gateway to Sustainable Agriculture.Journal of fungi (Basel, Switzerland) · 2025Review
237 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maize production is threatened by drought stress worldwide. Identification of the genetic components underlying drought tolerance in maize is of great importance. Here we report a genome-wide association study (GWAS) of maize drought tolerance at the seedling stage that identified 83 genetic variants, which were resolved to 42 candidate genes. The peak GWAS signal showed that the natural variation in ZmVPP1, encoding a vacuolar-type H(+) pyrophosphatase, contributes most significantly to the trait. Further analysis showed that a 366-bp insertion in the promoter, containing three MYB cis elements, confers drought-inducible expression of ZmVPP1 in drought-tolerant genotypes. Transgenic maize with enhanced ZmVPP1 expression exhibits improved drought tolerance that is most likely due to enhanced photosynthetic efficiency and root development. Taken together, this information provides important genetic insights into the natural variation of maize drought tolerance. The identified loci or genes can serve as direct targets for both genetic engineering and selection for maize trait improvement.
Indexed as
Identifiers
27526320What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.