ArticleThe American journal of surgical pathology2016
Lymphocytic Esophagitis in Nonachalasia Primary Esophageal Motility Disorders: Improved Criteria, Prevalence, Strength of Association, and Natural History.
Article in The American journal of surgical pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Clinical, endoscopic, and histologic characteristics of lymphocytic esophagitis: a systematic review.Esophagus : official journal of the Japan Esophageal Society · 2019Pooled it
- Lymphocytic oesophagitis: diagnosis and management.Clinical medicine (London, England) · 2023Review
- Chronic fibrosing esophagitis with diffuse esophageal intramural pseudo-diverticulosis.JGH open : an open access journal of gastroenterology and hepatology · 2022Review
- Lymphocytic Esophagitis: Assessing Risk Factors and Clinical Outcomes.Digestive diseases and sciences · 2021Article
- Lymphocytic Esophagitis With Predominance of CD4 T Cells and Expansion of Th1 Cells Is Associated With Achalasia.American journal of clinical pathology · 2021Article
- The hypercontractile esophagus: Still a tough nut to crack.Neurogastroenterology and motility · 2020Review
- Respiratory infections and chronic cough due to triple A (Allgrove) syndrome.Clinical case reports · 2020Article
- Upper gastrointestinal tract involvement of pediatric inflammatory bowel disease: A pathological review.World journal of gastroenterology · 2019Review
- A Positive Correlation Between Gastric and Esophageal Dysmotility Suggests Common Causality.Digestive diseases and sciences · 2018Article
- Mucosal inflammation in Candida esophagitis has distinctive features that may be helpful diagnostically.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2018Observational
- Esophagitis unrelated to reflux disease: current status and emerging diagnostic challenges.Virchows Archiv : an international journal of pathology · 2018Review
- Lymphocytic esophagitis: Still an enigma a decade later.World journal of gastroenterology · 2017Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Lymphocytic esophagitis (LE) is a histologic pattern with no established clinical correlates in the majority of patients. The goal of this study was to evaluate the association between nonachalasia primary esophageal motility disorders (PEMD) and LE. Sixty-nine patients with PEMD and esophageal biopsies, including 22 with nutcracker esophagus, 33 with ineffective motility, and 14 with diffuse spasm, constituted the study group. The control group consisted of 70 patients with severe dysmotility-negative gastroesophageal reflux disease requiring referral for Nissen fundoplication. To improve the criteria for LE, a lymphocyte reference range at different esophageal levels was first established in 17 healthy volunteers. The cutoffs for normal intraepithelial lymphocytes, defined as lymphocyte levels not exceeding mean level±2 SDs, were set at 62, 46, and 41 lymphocytes per high-power field at 0 to 2, 5, and 10 cm above the gastroesophageal junction, respectively. Predominantly focal peripapillary LE was observed in approximately 40% of patients with nutcracker esophagus or diffuse spasm and in 20% of patients with ineffective motility, in comparison with 4% of patients with dysmotility-negative gastroesophageal reflux disease (P<0.035 vs. any subtype of PEMD). Overall, LE was strongly associated with PEMD in multivariate analysis (adjusted odds ratio, 7.93; 95% confidence interval, 2.26-27.9; P=0.001). LE had a chronic course in 56% of the patients with follow-up biopsies. In conclusion, LE has a strong association with PEMD, suggesting the utility of LE in raising the possibility of PEMD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.