Evidence map›Paper›PMID 27526169›Full record

ArticleAdvances in experimental medicine and biology2016

Magnetization Transfer MRI Contrast May Correlate with Tissue Redox State in Prostate Cancer.

Rongwen Tain, He N Xu, Xiaohong J Zhou, Lin Z Li, Kejia Cai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in experimental medicine and biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rongwen TainDepartment of Radiology, Center for MR Research, University of Illinois at Chicago, 2242 w. Harrison st., Chicago, IL, 60612, USA.
He N XuBritton Chance Laboratory of Redox Imaging, Johnson Research Foundation; Department of Radiology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Xiaohong J ZhouDepartment of Radiology, Center for MR Research, University of Illinois at Chicago, 2242 w. Harrison st., Chicago, IL, 60612, USA.
Lin Z LiMolecular Imaging Laboratory, Department of Radiology, Britton Chance Laboratory of Redox Imaging, Johnson Research Foundation, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Kejia CaiDepartment of Radiology, Center for MR Research, University of Illinois at Chicago, 2242 w. Harrison st., Chicago, IL, 60612, USA. kcai@uic.edu.

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR029879 · NCRR · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MAZZONE, THEODORE · 2009 to 2011
$11.0M
A High-End 3 Tesla Human MRI Scanner Dedicated to ResearchS10RR028898 · NCRR · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ZHOU, XIAOHONG JOE · 2010 to 2010
$2.9M
Imaging Mitochondrial Redox States In Vivo by Hyperpolarized MRR01CA155348 · NCI · UNIVERSITY OF PENNSYLVANIA · PI LI, LIN Z · 2011 to 2015
$1.9M
NCI NIH HHS R01 CA155348NCRR NIH HHS S10 RR028898NCRR NIH HHS UL1 RR029879
6 · The paper itself

Abstract

Developing imaging biomarkers for non-invasive measurement of the tissue redox state is a key research area. Recently, we presented the first non-invasive MR imaging method that demonstrated the correlation between the endogenous chemical exchange saturation transfer (CEST) contrast and the tissue redox state. It is well known that the broadband magnetization transfer (MT) can occur via chemical exchange (CEST) and/or dipole-dipole interactions. The present study investigated if the broadband MT also correlated with the tissue redox state. The preliminary result for the prostate tumor xenografts indeed showed a significant correlation between the broadband MT contrast and the NADH redox ratio quantified with the optical redox scanning. In vivo MT contrast, once calibrated, may potentially serve as an imaging biomarker for tissue redox state.

Indexed as

AnimalsCell Line, TumorContrast MediaHeterograftsHumansMagnetic Resonance ImagingMaleMice, NudeNADNeoplasm TransplantationNeovascularization, PathologicOxidation-ReductionOxygenProstatic NeoplasmsTime FactorsTumor HypoxiaContrast MediaNADOxygenCESTMagnetization transferMRIOxidative stressProstate cancerRedox state

Identifiers

PMID27526169
PMCPMC5411113

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.