ArticleAdvances in experimental medicine and biology2016
Direct and Repeated Clinical Measurements of pO2 for Enhancing Cancer Therapy and Other Applications.
Article in Advances in experimental medicine and biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03321903 (Tumor Oximetry Using Electron Paramagnetic Resonance), which is not on this map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Tumor Oximetry Using Electron Paramagnetic Resonance (EPR) With India Ink (Using Carbon Particulates From Carlo Erba [CE])
Who cites it
16 citing papers in PubMed.
- Electron paramagnetic resonance (EPR) meets drug delivery and biomaterials: a magnetic love story.Drug delivery and translational research · 2026Review
- A Novel Approach to In Vivo EPR Spectroscopy for Repeatable Assessments of Oxygenation Levels in Tumors at Any Depth: Preliminary Feasibility Studies Utilizing a Multisite Oxygen Sensor Inside HDR Brachytherapy Needles.Advances in experimental medicine and biology · 2026Article
- Re-examining What the Results of "a Measurement of Oxygen Level in Tissues" Really Mean.Molecular imaging and biology · 2024Article
- Pulse and CW EPR Oximetry Using Oxychip in Gemcitabine-Treated Murine Pancreatic Tumors.Molecular imaging and biology · 2024Article
- Recognising Potential Ambiguities in Measurements of Oxygen in Tissues.Advances in experimental medicine and biology · 2024Article
- EPR Investigations to Study the Impact of Mito-Metformin on the Mitochondrial Function of Prostate Cancer Cells.Molecules (Basel, Switzerland) · 2022Article
- OxyChip embedded with radio-opaque gold nanoparticles for anatomic registration and oximetry in tissues.Magnetic resonance in medicine · 2022Article
- The Role of Imaging Biomarkers to Guide Pharmacological Interventions Targeting Tumor Hypoxia.Frontiers in pharmacology · 2022Review
- Evaluation of a Refined Implantable Resonator for Deep-Tissue EPR Oximetry in the Clinic.Applied magnetic resonance · 2021Article
- The impact of particulate electron paramagnetic resonance oxygen sensors on fluorodeoxyglucose imaging characteristics detected via positron emission tomography.Scientific reports · 2021Article
- What Is the Meaning of an Oxygen Measurement? : Analysis of Methods Purporting to Measure Oxygen in Targeted Tissues.Advances in experimental medicine and biology · 2021Article
- First-In-Human Study in Cancer Patients Establishing the Feasibility of Oxygen Measurements in Tumors Using Electron Paramagnetic Resonance With the OxyChip.Frontiers in oncology · 2021Article
- Characterization of a clinically used charcoal suspension for in vivo EPR oximetry.Magma (New York, N.Y.) · 2019Article
- Partial pressure of oxygen in the human body: a general review.American journal of blood research · 2019Review
- Wireless implantable coil with parametric amplification for in vivo electron paramagnetic resonance oximetric applications.Magnetic resonance in medicine · 2018Article
- Using India Ink as a Sensor for Oximetry: Evidence of its Safety as a Medical Device.Advances in experimental medicine and biology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
The first systematic multi-center study of the clinical use of EPR oximetry has begun, with funding as a PPG from the NCI. Using particulate oxygen sensitive EPR, materials in three complementary forms (India Ink, "OxyChips", and implantable resonators) the clinical value of the technique will be evaluated. The aims include using repeated measurement of tumor pO2 to monitor the effects of treatments on tumor pO2, to use the measurements to select suitable subjects for the type of treatment including the use of hyperoxic techniques, and to provide data that will enable existing clinical techniques which provide data relevant to tumor pO2 but which cannot directly measure it to be enhanced by determining circumstances where they can give dependable information about tumor pO2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.