ArticlePloS one2016
Synchronous Multiple Lung Adenocarcinomas: Estrogen Concentration in Peripheral Lung.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Omega-6/Omega-3 Ratio as a Protective Factor in Lung Cancer: A Mendelian Randomization Study on Polyunsaturated Fatty Acids and Lung Adenocarcinoma Risk.Journal of Cancer · 2025Article
- Expression of Concern: Synchronous Multiple Lung Adenocarcinomas: Estrogen Concentration in Peripheral Lung.PloS one · 2023Article
- Estrogen concentration and estrogen receptor-β expression in postmenopausal colon cancer considering patient/tumor background.Journal of cancer research and clinical oncology · 2022Article
- Estrogen synthesis in the stomach of Sprague-Dawley rats: comparison to Wistar rats.Experimental animals · 2021Article
- Sex Hormones and Lung Inflammation.Advances in experimental medicine and biology · 2021Article
- High Fat Diet Triggers a Reduction in Body Fat Mass in Female Mice Deficient for Utx demethylase.Scientific reports · 2019Article
- Intracrine Regulation of Estrogen and Other Sex Steroid Levels in Endometrium and Non-gynecological Tissues; Pathology, Physiology, and Drug Discovery.Frontiers in pharmacology · 2018Review
- Identification of microRNAs as potential biomarkers for lung adenocarcinoma using integrating genomics analysis.Oncotarget · 2017Article
- Estrogen, Estrogen Receptor and Lung Cancer.International journal of molecular sciences · 2017Review
Corrections and comments
- Expression of concern · 2023-01-11Conflict of Interest ·
- Expression of concern
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe detection rate of synchronous multiple lung adenocarcinomas (SMLA), which display multiple ground glass opacity nodules in the peripheral lung, is increasing due to advances in high resolution computed tomography. The backgrounds of multicentric development of adenocarcinoma are unknown. In this study, we quantitated estrogen concentration in the peripheral lungs of postmenopausal female patients with SMLA.
methodsThe tissue concentration of estrogens (estrone [E1] and estdadiol [E2]) in the noncancerous peripheral lung were measured with liquid chromatography/electrospray tandem mass spectrometry in postmenopausal female patients with lung adenocarcinoma. The expression levels of CYP19A1 in the normal lung were also quantitated with real-time PCR. Thirty patients with SMLA and 79 cases of control patients with single lung adenocarcinoma were analyzed.
resultsThe concentrations of E1 and E2 in the noncancerous tissue were significantly higher in SMLA cases than control cases (P = 0.004 and P = 0.02, respectively). The minor allele (A) of single nucleotide polymorphism rs3764221 were significantly associated with higher concentration of E1 and E2 (P = 0.002 and P = 0.01, respectively) and higher CYP19A1 mRNA expression (P = 0.03).
conclusionThe tissue estrogen concentration of peripheral lung was significantly higher in SMLA than control cases. The high concentration of estrogen may be one of the causes of multicentric development of peripheral lung adenocarcinomas.
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