ArticleJournal of experimental orthopaedics2016
Functional outcome measures in a surgical model of hip osteoarthritis in dogs.
Article in Journal of experimental orthopaedics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Actical Accelerometers as a Clinical Tool for the Monitoring of Sleeping and Resting Periods in Individual Dogs.Animals : an open access journal from MDPI · 2025Article
- Characterization of spatiotemporal and kinetic gait variables in dogs with hindlimb ataxia and bilateral hindlimb lameness.BMC veterinary research · 2024Article
- Enhanced Classification of Dog Activities with Quaternion-Based Fusion Approach on High-Dimensional Raw Data from Wearable Sensors.Sensors (Basel, Switzerland) · 2022Article
- Appendicular skeletal muscle mass assessment in dogs: a scoping literature review.BMC veterinary research · 2022Article
- Changes in Ground Reaction Forces and Center of Pressure Parameters of Paws When Wearing Dog Boots in Dogs.Frontiers in veterinary science · 2022Article
- Article
- Biological resurfacing in a canine model of hip osteoarthritis.Science advances · 2021Article
- The histopathology of the humeral head in glenohumeral osteoarthritis.Osteoarthritis and cartilage open · 2021Article
- Bridge-Enhanced Anterior Cruciate Ligament Repair Leads to Greater Limb Asymmetry and Less Cartilage Damage Than Untreated ACL Transection or ACL Reconstruction in the Porcine Model.The American journal of sports medicine · 2021Article
- Correlation of Artemin and GFRα3 With Osteoarthritis Pain: Early Evidence From Naturally Occurring Osteoarthritis-Associated Chronic Pain in Dogs.Frontiers in neuroscience · 2020Article
- LncRNA DNM3OS promotes proliferation and inhibits apoptosis through modulating IGF1 expression by sponging MiR-126 in CHON-001 cells.Diagnostic pathology · 2019Article
- The in vitro behaviour of canine osteoblasts derived from different bone types.BMC veterinary research · 2019Article
- The surgical destabilization of the abductor muscle leads to development of instability-associated hip osteoarthritis in mice.Journal of hip preservation surgeryArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundThe hip is one of the most common sites of osteoarthritis in the body, second only to the knee in prevalence. However, current animal models of hip osteoarthritis have not been assessed using many of the functional outcome measures used in orthopaedics, a characteristic that could increase their utility in the evaluation of therapeutic interventions. The canine hip shares similarities with the human hip, and functional outcome measures are well documented in veterinary medicine, providing a baseline for pre-clinical evaluation of therapeutic strategies for the treatment of hip osteoarthritis. The purpose of this study was to evaluate a surgical model of hip osteoarthritis in a large laboratory animal model and to evaluate functional and end-point outcome measures.
methodsSeven dogs were subjected to partial surgical debridement of cartilage from one femoral head. Pre- and postoperative pain and functional scores, gait analysis, radiographs, accelerometry, goniometry and limb circumference were evaluated through a 20-week recovery period, followed by histological evaluation of cartilage and synovium.
resultsAnimals developed histological and radiographic evidence of osteoarthritis, which was correlated with measurable functional impairment. For example, Mankin scores in operated limbs were positively correlated to radiographic scores but negatively correlated to range of motion, limb circumference and 20-week peak vertical force.
conclusionsThis study demonstrates that multiple relevant functional outcome measures can be used successfully in a large laboratory animal model of hip osteoarthritis. These measures could be used to evaluate relative efficacy of therapeutic interventions relevant to human clinical care.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.