Evidence map›Paper›PMID 27525641›Full record

ArticleObesity surgery2017

Influence of New Modified Biliopancreatic Diversion on Blood Glucose and Lipids in GK rats.

Shangeng Weng, Bin Zhang, Changguo Xu, Su Feng, Hongxing He

Abstract read
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In one paragraph

Article in Obesity surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Shangeng WengHepatopancreatobiliary Surgery Department, the First Affiliated Hospital of Fujian Medical University, No 20 Chazhong Road, Fuzhou City, Fujian, People's Republic of China. shangeng@sina.com.
Bin ZhangHepatopancreatobiliary Surgery Department, the First Affiliated Hospital of Fujian Medical University, No 20 Chazhong Road, Fuzhou City, Fujian, People's Republic of China.
Changguo XuHepatopancreatobiliary Surgery Department, the First Affiliated Hospital of Fujian Medical University, No 20 Chazhong Road, Fuzhou City, Fujian, People's Republic of China.
Su FengHepatopancreatobiliary Surgery Department, the First Affiliated Hospital of Fujian Medical University, No 20 Chazhong Road, Fuzhou City, Fujian, People's Republic of China.
Hongxing HeHepatopancreatobiliary Surgery Department, the First Affiliated Hospital of Fujian Medical University, No 20 Chazhong Road, Fuzhou City, Fujian, People's Republic of China.
First Affiliated Hospital of Fujian Medical University · CNFujian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to investigate the influence of new biliopancreatic diversion (NBPD) and duodenal-jejunal bypass (DJB) surgery on blood glucose, lipids, gastrointestinal hormones, and insulin in Goto-Kakizaki (GK) rats, an animal model for type 2 diabetes, in order to elucidate the mechanisms underlying the therapeutic effect of these types of surgery on this clinical condition.

methodsThirty 30 male GK rats (SPF) aged 12 weeks were randomly assigned into three groups (n = 10 per group): sham group, NBPD group, and DJB group. Body weight, random plasma glucose, fasting plasma glucose (FPG), oral glucose tolerance (OGT), blood lipids, plasma insulin, glucagon like peptide-1 (GLP-1), and gastric inhibitory polypeptide (GIP) were measured before and after surgery.

resultsNBPD surgery improved glucose tolerance, decreased fasting free fatty acids, triglycerides, and cholesterol. It also increased fasting and postprandial GIP, but caused no change in GLP-1. DJB surgery produced results similar to NBPD surgery except for causing a decrease in postprandial GLP-1 and insulin, and a larger increase in fasting GIP.

conclusionsMoving the biliopancreatic duct outlet to the mid-jejunum (NBPD surgery) improves glucose tolerance and increases GIP, but does not change GLP-1. Adding duodenal bypass (DJB surgery) increases fasting GIP and decreases postprandial GLP-1.

Indexed as

AnimalsBiliopancreatic DiversionBlood GlucoseDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2DuodenumGastric BypassGastric Inhibitory PolypeptideGlucagon-Like Peptide 1Glucose Tolerance TestInsulinInsulin ResistanceJejunumLipid MetabolismLipidsMaleBlood GlucoseGastric Inhibitory PolypeptideGlucagon-Like Peptide 1InsulinLipidsBiliopancreatic juiceDuodenal-jejunal bypassGoto-Kakizaki ratPlasma glucosePlasma lipid

Identifiers

PMID27525641
OpenAlexW2517390695

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.