Evidence map›Paper›PMID 27525640›Full record

ArticleObesity surgery2017

Decreased Levels of Circulating Cancer-Associated Protein Biomarkers Following Bariatric Surgery.

John Edward Farey, Oliver M Fisher, Angelique J Levert-Mignon, Patrice M Forner, Reginald V Lord

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Article in Obesity surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

John Edward FareyDepartment of Surgery, University of Notre Dame Australia, School of Medicine, Sydney, Darlinghurst, NSW, Australia.
Oliver M FisherDepartment of Surgery, University of Notre Dame Australia, School of Medicine, Sydney, Darlinghurst, NSW, Australia.
Angelique J Levert-MignonDepartment of Surgery, University of Notre Dame Australia, School of Medicine, Sydney, Darlinghurst, NSW, Australia.
Patrice M FornerDepartment of Surgery, University of Notre Dame Australia, School of Medicine, Sydney, Darlinghurst, NSW, Australia.
Reginald V LordDepartment of Surgery, University of Notre Dame Australia, School of Medicine, Sydney, Darlinghurst, NSW, Australia. rvlord@stvincents.com.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEpidemiological studies have identified obesity as a major risk factor for cancer in humans, and trials have demonstrated a significant reduction in the incidence of cancer after bariatric surgery. The rapidity of weight loss after bariatric surgery provides an opportunity to identify the molecular changes associated with effective obesity treatment. Indirectly, this may provide some insights into the mechanisms that drive the association between obesity and cancer. We sought to measure circulating cancer-associated proteins before and after laparoscopic sleeve gastrectomy (LSG).

methodsWe prospectively enrolled 15 patients undergoing LSG. Thirty-four plasma protein biomarkers thought to be associated with cancer processes were analyzed at baseline and following successful weight loss at 12 weeks using a multiplex bead-based assay.

resultsMean excess body weight loss was 44 % at 12-week follow-up. After LSG, a significant reduction in circulating plasma levels was observed for half (17/34) of the proteins assessed: VEGF-A, VEGF-C, VEGF-D, endoglin, PLGF, sFASL, IGFBP-1, IL-18, prolactin, EGF, TGFα, sCD40L, IL-18, TNFα, IL-6, HB-EGF, and PAI-1. Nonsignificant decreases were found for the remaining proteins.

conclusionsCirculating cancer-related biomarker levels were reduced by surgical weight loss, and this benefit was achieved as early as 3 months after operation. The observed reduction in cancer biomarkers may be related to the reported decrease in cancer incidence following bariatric surgery.

Indexed as

AdultBariatric SurgeryBiomarkers, TumorBody Mass IndexFemaleFollow-Up StudiesGastrectomyHumansLaparoscopyMaleMiddle AgedNeoplasm ProteinsObesity, MorbidRisk FactorsTreatment OutcomeWeight LossBiomarkers, TumorNeoplasm ProteinsBariatric surgeryBiological markersGastrectomyLaparoscopyNeoplasmsNeoplasms/prevention and control

Identifiers

PMID27525640
PMCPMC5306243

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.