Levonorgestrel in contraceptives and multipurpose prevention technologies: does this progestin increase HIV risk or interact with antiretrovirals?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

10 citing papers in PubMed.

1. HIV incidence among women using intramuscular depot medroxyprogesterone acetate, a copper intrauterine device, or a levonorgestrel implant for contraception: a randomised, multicentre, open-label trial.Lancet (London, England) · 2019
   Trial
2. Brief Report: Dapivirine Vaginal Ring Use Does Not Diminish the Effectiveness of Hormonal Contraception.Journal of acquired immune deficiency syndromes (1999) · 2017
   Trial
3. Pharmacokinetics, metabolism and serum concentrations of progestins used in contraception.Pharmacology & therapeutics · 2021
   Review
4. Use of Intrauterine Devices and Risk of Human Immunodeficiency Virus Acquisition Among Insured Women in the United States.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
   Article
5. Progestins Related to Progesterone and Testosterone Elicit Divergent Human Endometrial Transcriptomes and Biofunctions.International journal of molecular sciences · 2020
   Article
6. Rational Design of a Multipurpose Bioadhesive Vaginal Film for Co-Delivery of Dapivirine and Levonorgestrel.Pharmaceutics · 2019
   Article
7. Hormonal Contraception and HIV-1 Acquisition: Biological Mechanisms.Endocrine reviews · 2018
   Review
8. Progesterone-based compounds affect immune responses and susceptibility to infections at diverse mucosal sites.Mucosal immunology · 2017
   Review
9. Effects of intrauterine contraception on the vaginal microbiota.Contraception · 2017
   Article
10. Novel multipurpose pod-intravaginal ring for the prevention of HIV, HSV, and unintended pregnancy: Pharmacokinetic evaluation in a macaque model.PloS one · 2017
    Article

Corrections and comments

• Comment on
  An updated systematic review of epidemiological evidence on hormonal contraceptive methods and HIV acquisition in women.2016

Authors and funding

4 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

Indexed as