ArticleNature nanotechnology2016
Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions.
Article in Nature nanotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05348109 (Assessment of Decision Support System Software in Extraction and Anchorage Planning Among Adult Patients Using Computer Algorithm), which is not on this map. Cited by 296 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessment of Decision Support System Software in Extraction and Anchorage Planning Among Adult Patients Using Computer Algorithm
Who cites it
296 citing papers in PubMed.
- Magnetically actuated microrobots in urolithiasis: emerging frontiers in kidney stone diagnosis and management.Inflammopharmacology · 2026Review
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- Task-Oriented Biomedical Microrobots: Access, Working Environment, Actuation, Body Design, Detection and Control.Micromachines · 2026Review
- Review
- Artificial Versus Magneto-Aerotactic Bacterial Robots for Cancer Therapy.Micromachines · 2026Article
- Miniature Soft Robot With Magnetically Reprogrammable Surgical Functions.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Preclinical Optimization of Magnetotactic Bacteria Therapy for the Treatment of Pancreatic and Rectal Cancer.Cancers · 2026Article
- Living Microbial Drugs.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Deployment and clearance of microrobots for localized therapy: past, present and future.National science review · 2026Review
- Modular Biosurface Engineering of Magnetotactic Bacteria for Multimodal Synergistic Cancer Therapy.Chem & bio engineering · 2026Article
- Hydrogel-Based Micro/Nanorobots for Advanced Biomedical Applications.Gels (Basel, Switzerland) · 2026Review
- An inhalable microbe-oncolytic virus consortium for lung cancer treatment.Cell reports. Medicine · 2026Article
- Autonomous Cargo Transport with Biohybrid Microswimmers Enabled by Light-Mediated Bacteria-Cargo Communication.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Artificial chemotaxis in micro/nanomotors.Nature communications · 2026Review
- Targeting Cancers with Microrobots and Bacteriobots.Molecular biotechnology · 2026Review
- Synthesis and characterization of NIR-sensitive curcumin-gelatin nanoparticles for targeted drug delivery in 3D colon cancer.Scientific reports · 2026Article
- Enzymatic microbubble robots.Nature nanotechnology · 2026Article
- T cells assemble lentivirus to solve local delivery of stable gene therapy.Scientific reports · 2026Article
- Impact of oxidative stress onmBio · 2026Article
236 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
Abstract
Oxygen-depleted hypoxic regions in the tumour are generally resistant to therapies. Although nanocarriers have been used to deliver drugs, the targeting ratios have been very low. Here, we show that the magneto-aerotactic migration behaviour of magnetotactic bacteria, Magnetococcus marinus strain MC-1 (ref. 4), can be used to transport drug-loaded nanoliposomes into hypoxic regions of the tumour. In their natural environment, MC-1 cells, each containing a chain of magnetic iron-oxide nanocrystals, tend to swim along local magnetic field lines and towards low oxygen concentrations based on a two-state aerotactic sensing system. We show that when MC-1 cells bearing covalently bound drug-containing nanoliposomes were injected near the tumour in severe combined immunodeficient beige mice and magnetically guided, up to 55% of MC-1 cells penetrated into hypoxic regions of HCT116 colorectal xenografts. Approximately 70 drug-loaded nanoliposomes were attached to each MC-1 cell. Our results suggest that harnessing swarms of microorganisms exhibiting magneto-aerotactic behaviour can significantly improve the therapeutic index of various nanocarriers in tumour hypoxic regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.