ArticlePloS one2016
Plasma Prostaglandin E2 Levels Correlated with the Prevention of Intravenous Immunoglobulin Resistance and Coronary Artery Lesions Formation via CD40L in Kawasaki Disease.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Potential biomarkers to predict return to fertility after discontinuation of female contraceptives-looking to the future.Frontiers in reproductive health · 2023Review
- Atypical Substrates of the Organic Cation Transporter 1.Biomolecules · 2022Article
- Identification of rare coding variants associated with Kawasaki disease by whole exome sequencing.Genomics & informatics · 2021Article
- Homozygous ofFrontiers in genetics · 2021Article
- Insights into pediatric multi-system inflammatory syndrome and COVID-19.Clinica chimica acta; international journal of clinical chemistry · 2020Article
- The Expression of Glycoprotein Genes in the Inflammatory Process of Kawasaki Disease.Frontiers in pediatrics · 2020Article
- Increase expression of CD177 in Kawasaki disease.Pediatric rheumatology online journal · 2019Article
- Decreased DNA methyltransferases expression is associated with coronary artery lesion formation in Kawasaki disease.International journal of medical sciences · 2019Article
- Decreased Steroid Hormone ReceptorFrontiers in pediatrics · 2019Article
- Kawasaki Disease: The Role of Immune Complexes Revisited.Frontiers in immunology · 2019Review
- Article
- Epigenetic hypomethylation and upregulation of NLRC4 and NLRP12 in Kawasaki disease.Oncotarget · 2018Article
- Epigenetic hypomethylation and upregulation of matrix metalloproteinase 9 in Kawasaki disease.Oncotarget · 2017Article
- Anemia in Kawasaki Disease: Hepcidin as a Potential Biomarker.International journal of molecular sciences · 2017Review
- Regulatory T cell frequency, but not plasma IL-33 levels, represents potential immunological biomarker to predict clinical response to intravenous immunoglobulin therapy.Journal of neuroinflammation · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA form of systemic vasculitis, Kawasaki disease (KD) occurs most frequently in children under the age of five years old. Previous studies have found that Prostaglandin E2 (PGE2) correlates with KD, although the related mechanisms are still unknown. CD40L may also be a marker of vasculitis in KD, so this study focuses on PGE2 and CD40L expression in KD. MATERIALS AND
methodsThis study consisted of a total of 144 KD patients, whose intravenous immunoglobulin (IVIG)/coronary arterial lesion (CAL) formation resistance was evaluated. PGE2 levels were evaluated in vitro to study the effect of CD40L on CD4+ T lymphocytes.
resultsPGE2 levels significantly increased after IVIG treatment (p<0.05), especially in patients who responded to initial IVIG treatment (p = 0.004) and for patients without CAL formation (p = 0.016). Furthermore, an in vitro study revealed that IVIG acted as a trigger for PGE2 expression in the acute-stage mononuclear cells of KD patients. According to our findings, both IVIG and PGE2 can impede surface CD40L expressions on CD4+ T lymphocytes (p<0.05).
conclusionsThe results of this study are among the first to find that plasma PGE2 is correlated with the prevention of IVIG resistance and CAL formation through CD40L in KD.
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