ArticlePloS one2016
Noise Enhances Action Potential Generation in Mouse Sensory Neurons via Stochastic Resonance.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Transcutaneous spinal random noise stimulation enhances motor memory consolidation and corticospinal transmission in humans.The Journal of physiology · 2025Article
- Modulating excitation/inhibition balance through transcranial electrical stimulation: physiological mechanisms in animal models.Frontiers in neuroscience · 2025Review
- Cellular shortening and calcium dynamics are improved by noisy stimulus in a model of cardiomyopathy.Scientific reports · 2023Article
- Contrast detection is enhanced by deterministic, high-frequency transcranial alternating current stimulation with triangle and sine waveform.Journal of neurophysiology · 2023Article
- Random noise stimulation in the treatment of patients with neurological disorders.Neural regeneration research · 2022Review
- Emergence of stochastic resonance in a two-compartment hippocampal pyramidal neuron model.Journal of computational neuroscience · 2022Article
- Transcranial Random Noise Stimulation Acutely Lowers the Response Threshold of Human Motor Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Altering brain dynamics with transcranial random noise stimulation.Scientific reports · 2019Article
- Stochastic resonance enhances the rate of evidence accumulation during combined brain stimulation and perceptual decision-making.PLoS computational biology · 2018Article
- Modeling electrical stimulation of retinal ganglion cell with optimizing additive noises for reducing threshold and energy consumption.Biomedical engineering online · 2017Article
- Enabling electric field model of microscopically realistic brain.Brain stimulationArticle
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Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Noise can enhance perception of tactile and proprioceptive stimuli by stochastic resonance processes. However, the mechanisms underlying this general phenomenon remain to be characterized. Here we studied how externally applied noise influences action potential firing in mouse primary sensory neurons of dorsal root ganglia, modelling a basic process in sensory perception. Since noisy mechanical stimuli may cause stochastic fluctuations in receptor potential, we examined the effects of sub-threshold depolarizing current steps with superimposed random fluctuations. We performed whole cell patch clamp recordings in cultured neurons of mouse dorsal root ganglia. Noise was added either before and during the step, or during the depolarizing step only, to focus onto the specific effects of external noise on action potential generation. In both cases, step + noise stimuli triggered significantly more action potentials than steps alone. The normalized power norm had a clear peak at intermediate noise levels, demonstrating that the phenomenon is driven by stochastic resonance. Spikes evoked in step + noise trials occur earlier and show faster rise time as compared to the occasional ones elicited by steps alone. These data suggest that external noise enhances, via stochastic resonance, the recruitment of transient voltage-gated Na channels, responsible for action potential firing in response to rapid step-wise depolarizing currents.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.