Trial reportDiabetes research and clinical practice2016
Glycemic control and variability in association with body mass index and body composition over 18months in youth with type 1 diabetes.
Trial report in Diabetes research and clinical practice, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Effectiveness of medical nutrition therapy in adolescents with type 1 diabetes: a systematic review.Nutrition & diabetes · 2022Pooled it
- Are we close to defining a metabolomic signature of human obesity? A systematic review of metabolomics studies.Metabolomics : Official journal of the Metabolomic Society · 2019Pooled it
- Infant hyperglycemic excursions by saliva 1,5-anhydroglucitol varied by weight status, rapid weight gain, and mode of feeding: an exploratory secondary analysis.The American journal of clinical nutrition · 2026Trial
- Insulin Pump Therapy - Influence on Body Fat Redistribution, Skeletal Muscle Mass and Ghrelin, Leptin Changes in T1D Patients.Obesity facts · 2018Trial
- Significance of 8-iso-PGFAmerican heart journal plus : cardiology research and practice · 2026Review
- Physical Activity Is Associated With Improved Glycemic Outcomes in Newly Diagnosed Youth With Type 1 Diabetes: 4T Exercise Program.Diabetes care · 2025Article
- Metabolic syndrome in type 1 diabetes: higher time above range and glycemic variability revealed by continuous glucose monitoring (CGM).Diabetology & metabolic syndrome · 2025Article
- Effect of Body Weight on Glycaemic Indices in People with Type 1 Diabetes Using Continuous Glucose Monitoring.Journal of clinical medicine · 2024Article
- Glucose Variability in People with Type 1 Diabetes: Associations with Body Weight, Body Composition, and Insulin Sensitivity.Biomedicines · 2024Article
- Clinical relevance of short-term glycemic variability in children and adolescents with type 1 diabetes: a narrative review.Translational pediatrics · 2024Review
- Hypoglycemia and glycemic variability of people with type 1 diabetes with lower and higher physical activity loads in free-living conditions using continuous subcutaneous insulin infusion with predictive low-glucose suspend system.BMJ open diabetes research & care · 2023Article
- Article
- Clinical and humanistic impact of pharmacotherapeutic follow-up in patients with type 1 diabetes mellitus treated judicially.Diabetology & metabolic syndrome · 2022Article
- Technological Ecological Momentary Assessment Tools to Study Type 1 Diabetes in Youth: Viewpoint of Methodologies.JMIR diabetes · 2021Article
- Sociodemographic determinants of glycaemic control among children with type 1 diabetes in South Eastern Nigeria.The Pan African medical journal · 2021Article
- The Association of Targeted Gut Microbiota with Body Composition in Type 2 Diabetes Mellitus.International journal of medical sciences · 2021Observational
- Overweight and obese children with optimal control in the T1D Exchange Registry: How are they different from lean children with optimal control?Journal of diabetes and its complications · 2020Article
- Assessment of Cardiovascular Risk Factors in Patients with Type 2 Diabetes in Upper Egypt Villages.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
aimsThe impact of adiposity on glycemic control in type 1 diabetes patients has important implications for preventing complications. This study examined associations of glycemic outcomes with body mass index (BMI, kg/m(2)) and body composition in youth with type 1 diabetes.
methodsThis is a secondary analysis of an 18-month randomized controlled dietary intervention trial (N=136, baseline age=12.3±2.5y, HbA1c=8.1±1.0% (65±11mmol/mol)). Measured height and weight every 3months were abstracted from medical records. Body composition was assessed by dual energy X-ray absorptiometry (DXA) at baseline, 12 and 18months. Glycated hemoglobin (HbA1c) and glycemic variability assessed by masked 3-day continuous blood glucose monitoring (CGM) were obtained every 3months. 1,5-Anhydroglucitol (1,5-AG) was assessed every 6months. Adjusted random effects models for repeated measures estimated associations of time-varying BMI and body composition with time-varying glycemic outcomes.
resultsThere was no treatment effect on glycemic outcomes. HbA1c was not associated with BMI or body composition indicators. 1,5-AG was inversely associated with BMI and adiposity indicators (%fat, trunk fat mass and trunk %fat), adjusting for developmental covariates. Adiposity indicators were positively associated with %glucose >180mg/dL and >126mg/dL when adjusting for developmental covariates, and %glucose >126mg/dL when additionally adjusting for diabetes-related covariates. Fewer consistent relationships were observed for 3-day mean glucose and %glucose <70.2mg/dL. BMI and body composition variables were not associated with standard deviation of glycemic values or mean amplitude of glycemic excursions.
conclusionsThe role of greater BMI and adiposity in diabetes management in youth with type 1 diabetes may relate specifically to increased hyperglycemic excursions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.