ArticleInternational journal of reproductive biomedicine2016
Chronic restraint stress induces sperm acrosome reaction and changes in testicular tyrosine phosphorylated proteins in rats.
Article in International journal of reproductive biomedicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 54 citations in OpenAlex.
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- Sex differences in autonomic responses to stress: implications for cardiometabolic physiology.American journal of physiology. Endocrinology and metabolism · 2022Review
- Immobilization stress exacerbates arsenic-induced reprotoxic effects in adult rats.Toxicology research · 2022Article
- Effects of treadmill exercise on sexual behavior and reproductive parameters in chronically stressed-male rats.Physiological research · 2021Article
- Effect of Co-exposure to Heat and Psychological Stressors on Sperm DNA and Semen Parameters.Toxicology reports · 2021Article
- Comparison of male reproductive parameters in mice with type 1 and type 2 diabetes.Clinical and experimental reproductive medicine · 2020Article
- Identification of Sec23ip, Part of 14-3-3γ Protein Network, as a Regulator of Acute Steroidogenesis in MA-10 Leydig Cells.Endocrinology · 2020Article
- Expression of testicular phosphorylated proteins in types 1 and 2 diabetes mellitus in mice: An experimental study.International journal of reproductive biomedicine · 2019Article
- Testicular histopathology and phosphorylated protein changes in mice with diabetes induced by multiple-low doses of streptozotocin: An experimental study.International journal of reproductive biomedicine · 2018Article
- Valproic acid induces histologic changes and decreases androgen receptor levels of testis and epididymis in rats.International journal of reproductive biomedicine · 2017Article
- Effects of Chronic Stress and Comfort Food in Testicular Morphology in Adult Wistar Rats.International braz j urol : official journal of the Brazilian Society of UrologyArticle
- Phyllanthus emblica leaf extract ameliorates testicular damage in rats with chronic stress.Journal of Zhejiang University. Science. BArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStress is a cause of male infertility. Although sex hormones and sperm quality have been shown to be low in stress, sperm physiology and testicular functional proteins, such as phosphotyrosine proteins, have not been documented.
objectiveTo investigate the acrosome status and alterations of testicular proteins involved in spermatogenesis and testosterone synthesis in chronic stress in rats. MATERIALS AND
methodsIn this experimental study, male rats were divided into 2 groups (control and chronic stress (CS), n=7). CS rats were immobilized (4 hr/day) for 42 consecutive days. The blood glucose level (BGL), corticosterone, testosterone, acrosome status, and histopathology were examined. The expressions of testicular steroidogenic acute regulatory (StAR), cytochrome P450 side chain cleavage (CYP11A1), and phosphorylated proteins were analyzed.
resultsResults showed that BGL (71.25±2.22 vs. 95.60±3.36 mg/dl), corticosterone level (24.33±4.23 vs. 36.9±2.01 ng/ml), acrosome reacted sperm (3.25±1.55 vs. 17.71±5.03%), and sperm head abnormality (3.29±0.71 vs. 6.21±1.18%) were significantly higher in CS group in comparison with control. In contrast, seminal vesicle (0.41±0.05 vs. 0.24±0.07 g/100g), testosterone level (3.37±0.79 vs. 0.61±0.29 ng/ml), and sperm concentration (115.33±7.70 vs. 79.13±3.65×10(6) cells/ml) of CS were significantly lower (p<0.05) than controls. Some atrophic seminiferous tubules and low sperm mass were apparent in CS rats. The expression of CYP11A1 except StAR protein was markedly decreased in CS rats. In contrast, a 55 kDa phosphorylated protein was higher in CS testes.
conclusionCS decreased the expression of CYP11A, resulting in decreased testosterone, and increased acrosome-reacted sperm, assumed to be the result of an increase of 55 kDa phosphorylated protein.
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27525328PMC4971559W2517268195What OpenQuestion holds
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