Evidence map›Paper›PMID 27525310›Full record

ArticleJCI insight2016

Dual epithelial and immune cell function of Dvl1 regulates gut microbiota composition and intestinal homeostasis.

Haim Belinson, Adam K Savage, Douglas Fadrosh, Yien-Ming Kuo, Din Lin, Ricardo Valladares, Ysbrand Nusse, Anthony Wynshaw-Boris, Susan V Lynch, Richard M Locksley and 1 more

Abstract read
In one paragraph

Article in JCI insight, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
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  4. Review
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Haim BelinsonDepartment of Pediatrics and Institute for Human Genetics.
Adam K SavageHoward Hughes Medical Institute, Department of Microbiology & Immunology, and.
Douglas FadroshDepartment of Medicine, University of California, San Francisco, California, USA.
Yien-Ming KuoDepartment of Medicine, University of California, San Francisco, California, USA.
Din LinDepartment of Medicine, University of California, San Francisco, California, USA.
Ricardo ValladaresDepartment of Medicine, University of California, San Francisco, California, USA.
Ysbrand NusseDepartment of Pediatrics and Institute for Human Genetics.
Anthony Wynshaw-BorisDepartment of Pediatrics and Institute for Human Genetics.
Susan V LynchDepartment of Medicine, University of California, San Francisco, California, USA.
Richard M LocksleyHoward Hughes Medical Institute, Department of Microbiology & Immunology, and.
Ophir D KleinDepartment of Pediatrics and Institute for Human Genetics.

Funding

Role of miRNAs in Th2-Driven inflammation in AsthmaP01HL107202 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FAHY, JOHN V · 2012 to 2023
$23.3M
PREDOCTORAL TRAINING IN DEVELOPMENTAL BIOLOGYT32HD007470 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Todd Nystul · 1994 to 2026
$7.7M
Intestinal Stem Cell Consortium Coordinating CenterU01DK085532 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NILAND, JOYCE CAROL · 2009 to 2018
$6.5M
The roles of regional specialization, mechanical forces and epigenetic memory after perturbation and injury of the intestinal stem cell microenvironmentU01DK103147 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KLEIN, OPHIR D · 2014 to 2023
$5.4M
Limited Competition for the Continuation of the Intestinal Stem Cell Consortium Coordinating CenterU24DK085532 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NILAND, JOYCE CAROL · 2019 to 2023
$2.3M
NHLBI NIH HHS P01 HL107202NICHD NIH HHS T32 HD007470NIDDK NIH HHS U01 DK085532NIDDK NIH HHS U01 DK103147NIDDK NIH HHS U24 DK085532
6 · The paper itself

Abstract

Homeostasis of the gastrointestinal (GI) tract is controlled by complex interactions between epithelial and immune cells and the resident microbiota. Here, we studied the role of Wnt signaling in GI homeostasis using

Identifiers

PMID27525310
PMCPMC4979554

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.