ArticleCurrent opinion in behavioral sciences2016
Exposure to Early Life Pain: Long Term Consequences and Contributing Mechanisms.
Article in Current opinion in behavioral sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07281235 (Perioperative Analgesia With Ultrasound Guided Erector Spinae Block Versus Ultrasound Guided Caudal Block in Children), which is not on this map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Perioperative Analgesia With Ultrasound Guided Erector Spinae Block Versus Ultrasound Guided Caudal Block in Children
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effect of Intraoperative Regional Anesthesia on Postoperative Outcomes in Pediatric Cardiac Surgery-A Systematic Review of Randomized Controlled Trials.Paediatric anaesthesia · 2026Pooled it
- Long-term alterations in pain sensitivity following preterm birth: a systematic review and meta-analysis.Frontiers in pediatrics · 2026Pooled it
- The efficacy of oral sucrose for relieving lumbar puncture pain in neonates: a randomised clinical trial.BMJ paediatrics open · 2026Trial
- Effectiveness of non-immersive virtual reality in the management of procedure-related pain in preschool children: a randomized clinical trial.European journal of pediatrics · 2023Trial
- Fascial plane blocks in pediatric patients.Journal of anesthesia, analgesia and critical care · 2026Review
- Article
- Pain Measurement in Infants and Children With and at Risk for Intellectual Disabilities.Paediatric & neonatal pain · 2025Review
- Neonatal pain experience and pain sensitivity trajectories in preterm infants: A longitudinal study of flexion withdrawal reflex thresholds over the first two years of age.The journal of pain · 2025Article
- A cross-sectional analysis of brain structure, pain behaviors, and mental health in persons with surgically confirmed endometriosis.Communications biology · 2025Article
- Objective assessment of acute pain in foals using a facial expression-based pain scale.Equine veterinary journal · 2025Article
- Characterization of pain behaviors in kittens following ovariohysterectomy using video assessment.Scientific reports · 2025Article
- Noradrenergic Mechanisms and Circuitry of Hyperkatifeia in Alcohol Use Disorder.Biological psychiatry · 2025Review
- The Role of Maladaptive Plasticity in Modulating Pain Pressure Threshold Post-Spinal Cord Injury.Healthcare (Basel, Switzerland) · 2025Article
- Early-life pain alters excitability of corticotropin-releasing factor-expressing neurons in the central amygdala and stress-induced hypersensitivity during adolescence.Frontiers in behavioral neuroscience · 2025Article
- Pain experience and perception in individuals with Snijders Blok-Campeau syndrome.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Audio-Visual Distraction- A Non-Pharmacological Approach to Alleviate Pain in Pediatric Vaccine Administration: An Observational Study.JNMA; journal of the Nepal Medical Association · 2025Observational
- Neonatal intensive care nurses' assessment of preterm infants' pain and sedation: inter-rater reliability of the neonatal pain, agitation, and sedation scale.Frontiers in pediatrics · 2025Article
- Parent-perceived recurrent pain in children: associations with maternal pain, depressiveness, socioeconomic status, and children's behavioural difficulties.Frontiers in pediatrics · 2024Article
- Neonatal pain management practices in Somali region of Ethiopia: insights from neonatal intensive care unit providers.Frontiers in pediatrics · 2024Article
- Current Evidence for Biological Biomarkers and Mechanisms Underlying Acute to Chronic Pain Transition across the Pediatric Age Spectrum.Journal of clinical medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
From an evolutionary perspective, adaptations of an organism to its early environment are essential for survival. The occurrence of early life perturbation, coincident with increased developmental plasticity, provides a unique opportunity for such adaptations to become programmed and persist throughout life. However, adaptations that are beneficial to maintaining homeostasis in one's early environment may result in extreme response strategies that confer vulnerability or dysfunction later in life. This review summarizes recent findings in human and animal studies demonstrating that early life pain results in a hypo-/hyper-sensitive phenotype in response to acute and persistent pain and stress later in life. Changes in cognition and immune function in response to early life pain have also been observed. Recent data on the neural mechanisms underlying these long-term changes are discussed, as well as potential strategies to minimize the impact of early life pain.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.