Evidence map›Paper›PMID 27525229›Full record

ArticleBioImpacts : BI2016

Infection-resistant MRI-visible scaffolds for tissue engineering applications.

Morteza Mahmoudi, Mingming Zhao, Yuka Matsuura, Sophie Laurent, Phillip C Yang, Daniel Bernstein, Pilar Ruiz-Lozano, Vahid Serpooshan

Abstract read
In one paragraph

Article in BioImpacts : BI, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Image-Guided Cardiac Regeneration via a 3D Bioprinted Vascular Patch with Built-in CT Visibility.Chemical engineering journal (Lausanne, Switzerland : 1996) · 2025
    Article
  3. Collagen-Based Drug Delivery Agents for Glioblastoma Multiforme Treatment.International journal of molecular sciences · 2025
    Review
  4. Heterogeneous and Composite Bioinks for 3D-Bioprinting of Complex Tissue.Biomedical materials & devices (New York, N.Y.) · 2025
    Review
  5. X-Ray Visible Protein Scaffolds by Bulk Iodination.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. [Research progress on antibacterial properties of porous medical implant materials].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2020
    Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Imaging Biomaterial-Tissue Interactions.Trends in biotechnology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Morteza MahmoudiStanford Cardiovascular Institute, Stanford, CA, 94305 USA ; Division of Cardiovascular Medicine, Stanford University, 300 Pasteur Dr., Stanford, CA 94305 ; Nanotechnology Research Center and Department of Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 14155-6451, Iran.
Mingming ZhaoDepartment of Pediatrics, Stanford University, 300 Pasteur Dr., Stanford, CA 94305.
Yuka MatsuuraDivision of Cardiovascular Medicine, Stanford University, 300 Pasteur Dr., Stanford, CA 94305.
Sophie LaurentDepartment of General, Organic, and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, Avenue Maistriau, 19, B-7000 Mons, Belgium ; CMMI - Center for Microscopy and Molecular Imaging, Avenue A. Bolland, 8 B-6041 Gosselies, Belgium.
Phillip C YangStanford Cardiovascular Institute, Stanford, CA, 94305 USA ; Division of Cardiovascular Medicine, Stanford University, 300 Pasteur Dr., Stanford, CA 94305.
Daniel BernsteinStanford Cardiovascular Institute, Stanford, CA, 94305 USA ; Department of Pediatrics, Stanford University, 300 Pasteur Dr., Stanford, CA 94305.
Pilar Ruiz-LozanoStanford Cardiovascular Institute, Stanford, CA, 94305 USA ; Department of Pediatrics, Stanford University, 300 Pasteur Dr., Stanford, CA 94305.
Vahid SerpooshanStanford Cardiovascular Institute, Stanford, CA, 94305 USA ; Department of Pediatrics, Stanford University, 300 Pasteur Dr., Stanford, CA 94305.

Funding

GENETIC ABLATION OF EPICARDIAL FUNCTION IN THE MOUSER01HL065484 · NHLBI · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI RUIZ-LOZANO, PILAR · 2002 to 2012
$3.7M
ROLE OF BETA-RECEPTOR SIGNALING IN CARDIOMYOPATHYR01HL061535 · NHLBI · STANFORD UNIVERSITY · PI BERNSTEIN, DANIEL · 2000 to 2010
$3.3M
Genetic Rescue of Retinoid-Induced DysfunctionR01HL086879 · NHLBI · STANFORD UNIVERSITY · PI RUIZ-LOZANO, PILAR · 2009 to 2013
$1.7M
Genetic Ablation of Epicardial Function in the MouseR56HL065484 · NHLBI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI RUIZ-LOZANO, PILAR · 2007 to 2007
$478k
Molecular and Cellular Mechanisms of Neonatal Cardiac Development and RepairK99HL127295 · NHLBI · STANFORD UNIVERSITY · PI SERPOOSHAN, VAHID · 2016 to 2017
$238k
NHLBI NIH HHS K99 HL127295NHLBI NIH HHS R01 HL061535NHLBI NIH HHS R01 HL065484NHLBI NIH HHS R01 HL086879NHLBI NIH HHS R56 HL065484
6 · The paper itself

Abstract

Tissue engineering utilizes porous scaffolds as template to guide the new tissue growth. Clinical application of scaffolding biomaterials is hindered by implant-associated infection and impaired in vivo visibility of construct in biomedical imaging modalities. We recently demonstrated the use of a bioengineered type I collagen patch to repair damaged myocardium. By incorporating superparamagnetic iron oxide nanoparticles into this patch, here, we developed an MRI-visible scaffold. Moreover, the embedded nanoparticles impeded the growth of Salmonella bacteria in the patch. Conferring anti-infection and MRI-visible activities to the engineered scaffolds can improve their clinical outcomes and reduce the morbidity/mortality of biomaterial-based regenerative therapies.

Indexed as

Antibacterial propertiesCollagen scaffoldMagnetic resonance imagingnanoparticlesSPIONSuperparamagnetic iron oxideTissue engineering

Identifiers

PMID27525229
PMCPMC4981249

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.