Evidence map›Paper›PMID 27525023›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2016

Comparative Study of Chemical Composition and Biological Activity of Yellow, Green, Brown, and Red Brazilian Propolis.

Christiane Schineider Machado, João Benhur Mokochinski, Tatiana Onofre de Lira, Fátima de Cassia Evangelista de Oliveira, Magda Vieira Cardoso, Roseane Guimarães Ferreira, Alexandra Christine Helena Frankland Sawaya, Antonio Gilberto Ferreira, Cláudia Pessoa, Osmany Cuesta-Rubio and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
9.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 100 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Nano-Delivery System of Ethanolic Extract of Propolis TargetingNanomaterials (Basel, Switzerland) · 2023
    Article
  10. Brazilian Brown Propolis: an Overview About Its Chemical Composition, Botanical Sources, Quality Control, and Pharmacological Properties.Revista brasileira de farmacognosia : orgao oficial da Sociedade Brasileira de Farmacognosia · 2023
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Propolis characterization and antimicrobial activities againstSaudi journal of biological sciences · 2022
    Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Christiane Schineider MachadoDepartamento de Química, Universidade Estadual do Centro-Oeste (UNICENTRO), 85040-080 Guarapuava, PR, Brazil.
João Benhur MokochinskiDepartamento de Biologia Vegetal, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), 13083-862 Campinas, SP, Brazil.
Tatiana Onofre de LiraDepartamento de Química, Universidade Federal de São Carlos (UFSCar), 13565-905 São Carlos, SP, Brazil.
Fátima de Cassia Evangelista de OliveiraDepartamento de Fisiologia, Universidade Federal do Ceará (UFC), 60430-160 Fortaleza, CE, Brazil.
Magda Vieira CardosoPrograma de Pós-graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Pará (UFPA), Belém, PA, Brazil.
Roseane Guimarães FerreiraPrograma de Pós-graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Pará (UFPA), Belém, PA, Brazil.
Alexandra Christine Helena Frankland SawayaDepartamento de Biologia Vegetal, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), 13083-862 Campinas, SP, Brazil.
Antonio Gilberto FerreiraDepartamento de Química, Universidade Federal de São Carlos (UFSCar), 13565-905 São Carlos, SP, Brazil.
Cláudia PessoaDepartamento de Fisiologia, Universidade Federal do Ceará (UFC), 60430-160 Fortaleza, CE, Brazil; Fundação Oswaldo Cruz (Fiocruz), 60180-900 Fortaleza, CE, Brazil.
Osmany Cuesta-RubioUnidad Académica Ciencias Químicas y la Salud, Universidad Técnica de Machala, 070151 Machala, Ecuador.
Marta Chagas MonteiroPrograma de Pós-graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Pará (UFPA), Belém, PA, Brazil.
Mônica Soares de CamposDepartamento de Química, Universidade Estadual do Centro-Oeste (UNICENTRO), 85040-080 Guarapuava, PR, Brazil.
Yohandra Reyes TorresDepartamento de Química, Universidade Estadual do Centro-Oeste (UNICENTRO), 85040-080 Guarapuava, PR, Brazil.ORCID 0000-0003-1566-0223
Universidade Estadual do Centro-Oeste · BRUniversidade Federal do Pará · BRUniversidade Estadual de Campinas (UNICAMP) · BRUniversidade Federal de São Carlos · BRUniversidade Federal do Ceará · BRUniversidad Tecnica de Machala · EC

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The chemical composition and biological activity of a sample of yellow propolis from Mato Grosso do Sul, Brazil (EEP-Y MS), were investigated for the first time and compared with green, brown, and red types of Brazilian propolis and with a sample of yellow propolis from Cuba. Overall, EEP-Y MS had different qualitative chemical profiles, as well as different cytotoxic and antimicrobial activities when compared to the other types of propolis assessed in this study and it is a different chemotype of Brazilian propolis. Absence of phenolic compounds and the presence of mixtures of aliphatic compounds in yellow propolis were determined by analysing (1)H-NMR spectra and fifteen terpenes were identified by GC-MS. EEP-Y MS showed cytotoxic activity against human tumour strain OVCAR-8 but was not active against Gram-negative or Gram-positive bacteria. Our results confirm the difficulty of establishing a uniform quality standard for propolis from diverse geographical origins. The most appropriate pharmacological applications of yellow types of propolis must be further investigated.

Identifiers

PMID27525023
PMCPMC4972909
OpenAlexW2497111153

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.