ArticleStem cells international2016
Effects of Mechanical Stretch on Cell Proliferation and Matrix Formation of Mesenchymal Stem Cell and Anterior Cruciate Ligament Fibroblast.
Article in Stem cells international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 56 citations in OpenAlex.
- Biomechanical Stimulation of Mesenchymal Stem Cells in 3D Peptide Nanofibers for Bone Differentiation.Journal of functional biomaterials · 2026Article
- Mechanisms of Mucoid Degeneration in the Cruciate Ligament: Role of Denatured Aggrecan Accumulation and Tissue Dysfunction.Orthopedic research and reviews · 2026Review
- Mechanically induced dysregulation of calcium homeostasis: a molecular linchpin in asthmatic pathogenesis.European journal of medical research · 2025Review
- Integrating Modern Technologies into Traditional Anterior Cruciate Ligament Tissue Engineering.Bioengineering (Basel, Switzerland) · 2025Review
- Using Cell and Organ Culture Models to Analyze Responses of Bone Cells to Mechanical Stimulation.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Priming mesenchymal stem cells to develop "super stem cells".World journal of stem cells · 2024Article
- The modulating role of uniaxial straining in the IL-1β and TGF-β mediated inflammatory response of human primary ligamentocytes.Frontiers in bioengineering and biotechnology · 2024Article
- FGF-2 enriched nanofiber scaffold for advancing achilles tendon healing: a comparative experimental investigation.Frontiers in surgery · 2024Article
- Cyclic Stretching Triggers Cell Orientation and Extracellular Matrix Remodeling in a Periodontal Ligament 3D In Vitro Model.Advanced healthcare materials · 2023Article
- Mechanical stretch promotes apoptosis and impedes ciliogenesis of primary human airway basal stem cells.Respiratory research · 2023Article
- Nuclear softening mediated by Sun2 suppression delays mechanical stress-induced cellular senescence.Cell death discovery · 2023Article
- Mechanical Stress Improves Fat Graft Survival by Promoting Adipose-Derived Stem Cells Proliferation.International journal of molecular sciences · 2022Article
- Polarized M2 macrophages induced by mechanical stretching modulate bone regeneration of the craniofacial suture for midfacial hypoplasia treatment.Cell and tissue research · 2021Article
- Cyclically stretched ACL fibroblasts emigrating from spheroids adapt their cytoskeleton and ligament-related expression profile.Cell and tissue research · 2021Article
- A numerical framework for mechano-regulated tendon healing-Simulation of early regeneration of the Achilles tendon.PLoS computational biology · 2021Article
- Hydroxyapatite Nanoparticles Facilitate Osteoblast Differentiation and Bone Formation Within Sagittal Suture During Expansion in Rats.Drug design, development and therapy · 2021Article
- Bursa-Derived Cells Show a Distinct Mechano-Response to Physiological and Pathological LoadingFrontiers in cell and developmental biology · 2021Article
- Positive effects of platelet-rich plasma (PRP) and aPharmaceutical biology · 2020Article
- Fibroblast growth factor 2-induced human amniotic mesenchymal stem cells combined with autologous platelet rich plasma augmented tendon-to-bone healing.Journal of orthopaedic translation · 2020Article
- FGF-2-Induced Human Amniotic Mesenchymal Stem Cells Seeded on a Human Acellular Amniotic Membrane Scaffold Accelerated Tendon-to-Bone Healing in a Rabbit Extra-Articular Model.Stem cells international · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mesenchymal stem cells (MSCs) and fibroblasts are two major seed cells for ligament tissue engineering. To understand the effects of mechanical stimulation on these cells and to develop effective approaches for cell therapy, it is necessary to investigate the biological effects of various mechanical loading conditions on cells. In this study, fibroblasts and MSCs were tested and compared under a novel Uniflex/Bioflex culture system that might mimic mechanical strain in ligament tissue. The cells were uniaxially or radially stretched with different strains (5%, 10%, and 15%) at 0.1, 0.5, and 1.0 Hz. The cell proliferation and collagen production were compared to find the optimal parameters. The results indicated that uniaxial stretch (15% at 0.5 Hz; 10% at 1.0 Hz) showed positive effects on fibroblast. The uniaxial strains (5%, 10%, and 15%) at 0.5 Hz and 10% strain at 1.0 Hz were favorable for MSCs. Radial strain did not have significant effect on fibroblast. On the contrary, the radial strains (5%, 10%, and 15%) at 0.1 Hz had positive effects on MSCs. This study suggested that fibroblasts and MSCs had their own appropriate mechanical stimulatory parameters. These specific parameters potentially provide fundamental knowledge for future cell-based ligament regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.