ArticleAdvanced functional materials2016
Multifunctional Magnetic Particles for Combined Circulating Tumor Cells Isolation and Cellular Metabolism Detection.
Article in Advanced functional materials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 108 citations in OpenAlex.
- Plasmonic silver nanoshells for drug and metabolite detection.Nature communications · 2017Trial
- A Nanoparticle-Coated Cellulose Acetate Membrane for Highly Efficient, Low-Cost Circulating Tumor Cell Detection.Biosensors · 2024Article
- Research progress on the multi-omics and survival status of circulating tumor cells.Clinical and experimental medicine · 2024Review
- Organic metal chalcogenide-assisted metabolic molecular diagnosis of central precocious puberty.Chemical science · 2023Article
- Construction of a ternary component chip with enhanced desorption efficiency for laser desorption/ionization mass spectrometry based metabolic fingerprinting.Frontiers in bioengineering and biotechnology · 2023Article
- Metabolic Molecular Diagnosis of Inflammatory Bowel Disease by Synergistical Promotion of Layered Titania Nanosheets with Graphitized Carbon.Phenomics (Cham, Switzerland) · 2022Article
- One-Chip Isolation of Drug-Resistant Acute Myeloid Leukemia Cells with CXCR4-Targeted Magnetic Fluorescent Nanoprobes.Nanomaterials (Basel, Switzerland) · 2022Article
- Dual-modality loop-mediated isothermal amplification for pretreatment-free detection of Septin9 methylated DNA in colorectal cancer.Mikrochimica acta · 2021Article
- Immunoengineered magnetic-quantum dot nanobead system for the isolation and detection of circulating tumor cells.Journal of nanobiotechnology · 2021Article
- Field-effect transistor bioassay for ultrasensitive detection of folate receptor 1 by ligand-protein interaction.Mikrochimica acta · 2020Article
- Rapid Computer-Aided Diagnosis of Stroke by Serum Metabolic Fingerprint Based Multi-Modal Recognition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Machine learning of serum metabolic patterns encodes early-stage lung adenocarcinoma.Nature communications · 2020Article
- Negative depletion mediated brightfield circulating tumour cell identification strategy on microparticle-based microfluidic chip.Journal of nanobiotechnology · 2020Article
- Bead based facile assay for sensitive quantification of native state green fluorescent protein.RSC advances · 2020Article
- Janus particles: design, preparation, and biomedical applications.Materials today. Bio · 2019Review
- Design of plasmonic nanomaterials for diagnostic spectrometry.Nanoscale advances · 2019Review
- Colorimetric immunoassay for Listeria monocytogenes by using core gold nanoparticles, silver nanoclusters as oxidase mimetics, and aptamer-conjugated magnetic nanoparticles.Mikrochimica acta · 2018Article
- Advances in liquid biopsy on-chip for cancer management: Technologies, biomarkers, and clinical analysis.Critical reviews in clinical laboratory sciences · 2018Review
- Metabolic Fingerprinting on a Plasmonic Gold Chip for Mass Spectrometry BasedACS central science · 2018Article
- Applications of liquid biopsy in lung cancer-diagnosis, prognosis prediction, and disease monitoring.American journal of translational research · 2018Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
We for the first time demonstrate multi-functional magnetic particles based rare cell isolation combined with the downstream laser desorption/ionization mass spectrometry (LDI-MS) to measure the metabolism of enriched circulating tumor cells (CTCs). The characterization of CTCs metabolism plays a significant role in understanding the tumor microenvironment, through exploring the diverse cellular process. However, characterizing cell metabolism is still challenging due to the low detection sensitivity, high sample complexity, and tedious preparation procedures, particularly for rare cells analysis in clinical study. Here we conjugate ferric oxide magnetic particles with anti-EpCAM on the surface for specific, efficient enrichment of CTCs from PBS and whole blood with cells concentration of 6-100 cells per mL. Moreover, these hydrophilic particles as matrix enable sensitive and selective LDI-MS detection of small metabolites (MW<500 Da) in complex bio-mixtures and can be further coupled with isotopic quantification to monitor selected molecules metabolism of ~50 CTCs. Our unique approach couples the immunomagnetic separation of CTCs and LDI-MS based metabolic analysis, which represents a key step forward for downstream metabolites analysis of rare cells to investigate the biological features of CTCs and their cellular responses in both pathological and physiological phenomena.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.