Evidence map›Paper›PMID 27524894›Full record

ArticleInternational journal of nanomedicine2016

A novel temperature-responsive micelle for enhancing combination therapy.

Cheng-Liang Peng, Yuan-I Chen, Hung-Jen Liu, Pei-Chi Lee, Tsai-Yueh Luo, Ming-Jium Shieh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Chonnam medical journal · 2017
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Cheng-Liang PengIsotope application Division, Institute of Nuclear energy research, Taoyuan.
Yuan-I ChenInstitute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei; Department of Oncology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.
Hung-Jen LiuInstitute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei.
Pei-Chi LeeInstitute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei.
Tsai-Yueh LuoIsotope application Division, Institute of Nuclear energy research, Taoyuan.
Ming-Jium ShiehInstitute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei; Department of Oncology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.
National Taiwan University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel thermosensitive polymer p(N-isopropylacrylamide-co-poly[ethylene glycol] methyl ether acrylate)-block-poly(epsilon-caprolactone), p(NIPAAM-co-PEGMEA)-b-PCL, was synthesized and developed as nanomicelles. The hydrophobic heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin and the photosensitizer cyanine dye infrared-780 were loaded into the core of the micelles to achieve both chemotherapy and photothermal therapy simultaneously at the tumor site. The release of the drug could be controlled by varying the temperature due to the thermosensitive nature of the micelles. The micelles were less than 200 nm in size, and the drug encapsulation efficiency was >50%. The critical micelle concentrations were small enough to allow micelle stability upon dilution. Data from cell viability and animal experiments indicate that this combination treatment using photothermal therapy with chemotherapy had synergistic effects while decreasing side effects.

Indexed as

MicellesTemperatureAcrylic ResinsAnimalsAntineoplastic AgentsBenzoquinonesDrug CarriersDrug LiberationDrug SynergismDrug Therapy, CombinationHCT116 CellsHumansIndolesInfrared RaysLactams, MacrocyclicMice, Nude2-(2-(2-chloro-3-((1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)ethylidene)-1-cyclohexen-1-yl)ethenyl)-3,3-dimethyl-1-propylindoliumAcrylic ResinsAntineoplastic AgentsBenzoquinonesDrug CarriersIndolesLactams, MacrocyclicMicellespolycaprolactonePolyesterspoly-N-isopropylacrylamidetanespimycinchemotherapycontrol releasenanocarrierphotothermal therapysynergistic effectthermosensitive

Identifiers

PMID27524894
PMCPMC4966578
OpenAlexW2486492025

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.