Evidence map›Paper›PMID 27524885›Full record

ReviewPatient preference and adherence2016

Poor medication adherence in type 2 diabetes: recognizing the scope of the problem and its key contributors.

William H Polonsky, Robert R Henry

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Patient preference and adherence, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02621476 (Encouraging Mail Order Pharmacy Use to Improve Outcomes and Reduce Disparities), which is not on this map. Cited by 375 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
375citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02621476 nacompletednot on this mapstarted 2017, after this paper: background citation

Encouraging Mail Order Pharmacy Use to Improve Outcomes and Reduce Disparities

TypeinterventionalSponsorKaiser PermanenteRan2017 to 2022Enrolled63,012ConditionsDiabetes MellitusArmsStandardized intervention, Usual care
3 · Its place in the literature

Who cites it

375 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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  15. A Single Sauna Session Does Not Improve Postprandial Blood Glucose Handling in Individuals with Type 2 Diabetes Mellitus: A Cross-Over, Randomized, Controlled Trial.Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association · 2024
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315 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

William H PolonskyBehavioral Diabetes Institute, San Diego; University of California, San Diego.
Robert R HenryUniversity of California, San Diego; Center for Metabolic Research, VA San Diego Healthcare System, San Diego, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

At least 45% of patients with type 2 diabetes (T2D) fail to achieve adequate glycemic control (HbA1c <7%). One of the major contributing factors is poor medication adherence. Poor medication adherence in T2D is well documented to be very common and is associated with inadequate glycemic control; increased morbidity and mortality; and increased costs of outpatient care, emergency room visits, hospitalization, and managing complications of diabetes. Poor medication adherence is linked to key nonpatient factors (eg, lack of integrated care in many health care systems and clinical inertia among health care professionals), patient demographic factors (eg, young age, low education level, and low income level), critical patient beliefs about their medications (eg, perceived treatment inefficacy), and perceived patient burden regarding obtaining and taking their medications (eg, treatment complexity, out-of-pocket costs, and hypoglycemia). Specific barriers to medication adherence in T2D, especially those that are potentially modifiable, need to be more clearly identified; strategies that target poor adherence should focus on reducing medication burden and addressing negative medication beliefs of patients. Solutions to these problems would require behavioral innovations as well as new methods and modes of drug delivery.

Indexed as

glycemic controlHbA1chypoglycemiamedication adherencepsychosocialtype 2 diabetes

Identifiers

PMID27524885
PMCPMC4966497

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.